Department of Oncology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Tiexi District, Shenyang City, Liaoning Province 110022, China.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Tiexi District, Shenyang City, Liaoning Province 110022, China.
Biomed Pharmacother. 2024 Nov;180:117553. doi: 10.1016/j.biopha.2024.117553. Epub 2024 Oct 13.
Gynecological cancers rank among the leading causes of death for women worldwide. Traditional treatment methods, including surgery, chemotherapy, and radiotherapy, are commonly employed in patients with these tumors. However, the effectiveness of these approaches remains suboptimal due to issues like treatment resistance and challenges in early detection. As an alternative, immunotherapy has shown promise by offering improved anti-tumor responses and fewer side effects. In recent years, there have been significant advances in nanoparticle (NP) and nanoengineering technologies, paving the way for the development of nano-immunotherapy-an approach designed to enhance the effectiveness of immunotherapy. Thanks to the flexibility, adaptability, small size, and responsiveness of NP platforms to the tumor microenvironment (TME), nano-immunotherapy has demonstrated improved anti-tumor activity and safety. This is achieved through enhanced tumor targeting, better delivery of immune agents, and reduced toxicity and side effects. Recently, researchers have explored the application of nano-immunotherapy in treating gynecological cancers, aiming to slow tumor progression and improve patient outcomes. In this review, we provide an overview of the latest advances in nano-immunotherapy for gynecological cancers, including ovarian, cervical, and endometrial cancers. Additionally, we discuss the challenges facing the clinical translation of nano-immunotherapy from the lab to real-world applications.
妇科癌症是全球女性死亡的主要原因之一。传统的治疗方法，包括手术、化疗和放疗，通常用于治疗这些肿瘤的患者。然而，由于治疗耐药性和早期检测的挑战等问题，这些方法的效果仍然不尽如人意。作为一种替代方法，免疫疗法通过提供改善的抗肿瘤反应和更少的副作用显示出了希望。近年来，纳米粒子（NP）和纳米工程技术取得了重大进展，为开发纳米免疫疗法铺平了道路，这种方法旨在提高免疫疗法的效果。由于 NP 平台对肿瘤微环境（TME）的灵活性、适应性、小尺寸和响应性，纳米免疫疗法已经显示出了改善的抗肿瘤活性和安全性。这是通过增强肿瘤靶向、更好地递送免疫制剂以及减少毒性和副作用来实现的。最近，研究人员探索了纳米免疫疗法在治疗妇科癌症中的应用，旨在减缓肿瘤进展并改善患者的预后。在这篇综述中，我们概述了纳米免疫疗法在治疗妇科癌症方面的最新进展，包括卵巢癌、宫颈癌和子宫内膜癌。此外，我们还讨论了将纳米免疫疗法从实验室转化为实际应用所面临的挑战。
