Gedda Gangaraju, Park Yoo-Jin, Pang Myung-Geol
Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Korea.
Central Research Laboratory, KS Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru, India.
Obstet Gynecol Sci. 2025 Jan;68(1):18-29. doi: 10.5468/ogs.24180. Epub 2024 Nov 26.
Gynecological cancer is a life-threatening malignancy among women. Traditional therapies, including chemotherapy, often face challenges in terms of chemotherapeutic drug solubility and resistance, specificity, tumor site targeting, and toxicity to healthy tissues, leading to shortened efficacy and unfavorable patient outcomes and survival rates in patients with gynecologic malignancies. Recently, nanotechnology-based therapeutic methods such as targeted drug delivery and phototherapies have emerged as an appropriate alternative to overcome issues associated with traditional therapeutic methods. Specifically, nanomaterials and nanomaterial-based methods enhance the delivery of therapeutic/targeting agents to tumor sites and cellular uptakes and improve the tumor-suppressing effect. This review aims to provide an overview and future perspective on the potential impact of nanotechnology-based therapeutic methods for effective therapies for gynecologic cancer.
妇科癌症是威胁女性生命的恶性肿瘤。包括化疗在内的传统疗法在化疗药物的溶解性和耐药性、特异性、肿瘤部位靶向性以及对健康组织的毒性等方面常常面临挑战，导致妇科恶性肿瘤患者的疗效缩短，患者预后和生存率不佳。近年来，基于纳米技术的治疗方法，如靶向药物递送和光疗法，已成为克服传统治疗方法相关问题的合适替代方案。具体而言，纳米材料和基于纳米材料的方法可增强治疗/靶向剂向肿瘤部位的递送和细胞摄取，并提高肿瘤抑制效果。本综述旨在概述基于纳米技术的治疗方法对妇科癌症有效治疗的潜在影响，并展望其未来前景。
