Abudurezake Abulaiti, Kakehi Saori, Umemura Futaba, Kaga Hideyoshi, Someya Yuki, Tabata Hiroki, Yoshizawa Yasuyo, Naito Hitoshi, Tajima Tsubasa, Ito Naoaki, Otsuka Hikaru, Shi Huicong, Sugimoto Mari, Sakamoto Shota, Muroga Yukiko, Wakabayashi Hidetaka, Kawamori Ryuzo, Watada Hirotaka, Tamura Yoshifumi
Sportology Center, Graduate School of Medicine, Juntendo University, Bunkyo, Tokyo, Japan.
Sportology Center, Graduate School of Medicine, Juntendo University, Bunkyo, Tokyo, Japan; Department of Sports Medicine and Sportology, Graduate School of Medicine, Juntendo University, Bunkyo, Tokyo, Japan.
Arch Med Res. 2025 Jan;56(1):103095. doi: 10.1016/j.arcmed.2024.103095. Epub 2024 Oct 14.
Sarcopenia has been with a decrease in masseter muscle (MM) thickness in high-risk older populations. However, the relationship between sarcopenia and determinants of MM volume (MMV) in the general elderly population remains unclear.
In a cross-sectional study of 1,484 older adults in Tokyo, we evaluated MMV using 3D MRI scanning, appendicular skeletal muscle mass (ASMM), handgrip strength, dietary intake, smoking, insulin-like growth factor 1 (IGF-1) levels, and the ACTN3 R577X polymorphism. Participants were divided into quintiles based on MMV (Q1-5).
Participants in our study had a mean age of 73.0 ± 5.3 years and their MMV (Men: 35.3 ± 7.8 mL, Women: 25.0 ± 5.1 mL) was significantly higher in men than in women. A significant association between MMV and sarcopenia was observed, with the lowest quintile (Q1) showing a higher risk compared to the highest quintile (Q5) in both sexes. Body mass index (BMI) and age were independent determinants of ASMM in both sexes, whereas BMI, but interestingly not age, was a determinant of MMV. Moreover, IGF-1 was positively correlated with MMV in both sexes; smoking was negatively correlated with MMV in women. The ACTN3 577XX genotype was only associated with smaller MMV in men.
Low MMV increased the risk of sarcopenia, particularly in men. BMI and age strongly influenced ASMM, while MMV was only weakly associated with BMI and not with age. Notably, IGF-1 level was positively associated with MMV only, and ACTN3 genotype was associated to reduced MMV only in men.
在高危老年人群中，肌肉减少症与咬肌（MM）厚度降低有关。然而，在一般老年人群中，肌肉减少症与MM体积（MMV）的决定因素之间的关系仍不清楚。
在一项对东京1484名老年人的横断面研究中，我们使用三维磁共振成像扫描、四肢骨骼肌质量（ASMM）、握力、饮食摄入、吸烟、胰岛素样生长因子1（IGF-1）水平和α-辅肌动蛋白3（ACTN3）R577X多态性来评估MMV。参与者根据MMV分为五等分（Q1-5）。
我们研究中的参与者平均年龄为73.0±5.3岁，男性的MMV（35.3±7.8 mL）显著高于女性（25.0±5.1 mL）。观察到MMV与肌肉减少症之间存在显著关联，在两个性别中，最低五分位数（Q1）与最高五分位数（Q5）相比显示出更高的风险。体重指数（BMI）和年龄是两性ASMM的独立决定因素，而BMI是MMV的决定因素，但有趣的是年龄不是。此外，IGF-1在两性中均与MMV呈正相关；吸烟在女性中与MMV呈负相关。ACTN3 577XX基因型仅与男性较小的MMV相关。
低MMV增加了肌肉减少症的风险，尤其是在男性中。BMI和年龄强烈影响ASMM，而MMV仅与BMI弱相关，与年龄无关。值得注意的是，IGF-1水平仅与MMV呈正相关，ACTN3基因型仅在男性中与MMV降低相关。
