Zhang Yue, Yang Xuehan, Zhao Yawei, Chen Fangman, Shi Tongfei, Wu Ziping, Chen Xuenian, Zhang Ming, Chen Li
Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114308. doi: 10.1016/j.colsurfb.2024.114308. Epub 2024 Oct 9.
The global crisis of antibiotic resistance has impelled the exigency to develop more effective drug delivery systems for the treatment of bacterial infection. The development of possessing high biocompatibility and targeted delivery of antimicrobials remains a persisting challenge. For programmable release of efficient antimicrobials in infection sites to enhance antibacterial activity, herein, we fabricated diselenide-bridged mesoporous organosilica nanoparticle-supported silver nanoparticles (Ag NPs) with high drug-loading capacity for the co-delivery of tobramycin (TOB) within one drug delivery system (Ag-MON@TOB (Se)). The resultant Ag-MON@TOB (Se) exhibited favorable biocompatibility due to its high stability in the physiological condition. Notably, such Ag-MON@TOB (Se) manifested a programmable structural destabilization to trigger sequential drug release in response to the oxidative stimuli within the bacterial infection microenvironment. In contradistinction to the oxidation-stable disulfide bond moieties within the framework of the nanocarrier (Ag-MON@TOB (S)), the Ag-MON@TOB (Se) with its programmed drug release behavior augmented prominent antibacterial therapy both in vitro and in vivo. This work represents a promising strategy for programmable drug release by harnessing a responsive degradable vehicle to enhance the treatment of bacterial infection.
全球抗生素耐药性危机促使人们迫切需要开发更有效的药物递送系统来治疗细菌感染。开发具有高生物相容性和抗菌药物靶向递送功能的系统仍然是一个长期存在的挑战。为了在感染部位实现高效抗菌药物的可编程释放以增强抗菌活性，在此，我们制备了具有高载药能力的二硒键桥连介孔有机硅纳米颗粒负载银纳米颗粒（Ag NPs），用于在一个药物递送系统（Ag-MON@TOB (Se)）中共递送妥布霉素（TOB）。所得的Ag-MON@TOB (Se)由于在生理条件下具有高稳定性而表现出良好的生物相容性。值得注意的是，这种Ag-MON@TOB (Se)表现出可编程的结构去稳定化，以响应细菌感染微环境中的氧化刺激而触发顺序药物释放。与纳米载体（Ag-MON@TOB (S)）框架内氧化稳定的二硫键部分不同，具有可编程药物释放行为的Ag-MON@TOB (Se)在体外和体内均增强了显著的抗菌治疗效果。这项工作代表了一种通过利用响应性可降解载体实现可编程药物释放以增强细菌感染治疗的有前景的策略。
