Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Urology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, China.
Ecotoxicol Environ Saf. 2024 Nov 1;286:117189. doi: 10.1016/j.ecoenv.2024.117189. Epub 2024 Oct 14.
Glyphosate has been ubiquitously present in our living environment due to its efficient herbicidal ability, but its association with the prevalence of kidney stones remains uncertain. This study aims to explore the impact of glyphosate exposure on kidney stones and to investigate the mediating effects of some serologic indicators. Furthermore, we attempt to identify the specific populations at greater risk of exposure.
This is a cross-sectional study of the U.S. adult population examining the association between glyphosate exposure and kidney stones based on data from the 2013-2018 National Health and Nutrition Examination Survey (NHANES). We implemented multi-model-adjusted logistic regression and smoothed curve fitting to explore the connection between them. Further subgroup analyses were conducted to confirm the magnitude of exposure risk in specific populations. Mediation effects analysis served to provide insight into the underlying mechanisms of the link.
A total of 4302 participants' health data were ultimately analyzed, and the prevalence of kidney stones was 10.85 %. Participants with the highest urinary glyphosate(uGLY) content(Q3) had a higher prevalence of kidney stones compared with participants with the lowest uGLY content(Q1) (OR=1.70, 95 %CI: 1.10-2.63). Smoothed curve fitting revealed a linear positive association between ln-transformed uGLY and kidney stones (OR=1.21,95 %CI:1.08-1.37, LLR=0.291), and this exposure-outcome effect was at greater risk in men (OR=1.24,95 %CI: 1.05-1.46), non-Hispanic whites (OR=1.29, 95 %CI: 1.09-1.53), and hypertensive groups (OR=1.23,95 %CI: 1.05-1.44). Serum biochemical markers HDL, ALP, and serum glucose partially mediated the correlation between glyphosate and kidney stones (2.44-4.20 %).
Glyphosate exposure is significantly associated with the prevalence of kidney stones. In men, non-Hispanic whites, and hypertensive populations, the management of glyphosate exposure should be emphasized, and appropriate protective strategies may be beneficial in reducing the burden of kidney stones. More high-quality clinical inquiries and animal toxicology experiments are still required to verify the reliability of our findings and their underlying mechanisms.
由于其高效的除草能力，草甘膦在我们的生活环境中无处不在，但它与肾结石的流行之间的关系尚不确定。本研究旨在探讨草甘膦暴露对肾结石的影响，并研究一些血清学指标的介导作用。此外，我们试图确定易受暴露影响的特定人群。
这是一项基于美国 2013-2018 年全国健康和营养调查（NHANES）数据的横断面研究，旨在探讨草甘膦暴露与肾结石之间的关系。我们采用多模型调整的逻辑回归和平滑曲线拟合来探索它们之间的联系。进一步的亚组分析用于确认特定人群的暴露风险程度。中介效应分析提供了对联系潜在机制的深入了解。
最终分析了 4302 名参与者的健康数据，肾结石的患病率为 10.85%。尿液草甘膦(uGLY)含量最高的 Q3 组参与者与尿液草甘膦(uGLY)含量最低的 Q1 组参与者相比，肾结石的患病率更高（OR=1.70，95%CI：1.10-2.63）。平滑曲线拟合显示 ln 变换的 uGLY 与肾结石之间存在线性正相关（OR=1.21，95%CI：1.08-1.37，LLR=0.291），这种暴露-结果效应在男性（OR=1.24，95%CI：1.05-1.46）、非西班牙裔白人（OR=1.29，95%CI：1.09-1.53）和高血压组（OR=1.23，95%CI：1.05-1.44）中风险更高。血清生化标志物 HDL、ALP 和血清葡萄糖部分介导了草甘膦与肾结石之间的相关性（2.44-4.20%）。
草甘膦暴露与肾结石的患病率显著相关。在男性、非西班牙裔白人和高血压人群中，应强调草甘膦暴露的管理，采取适当的保护策略可能有助于减轻肾结石的负担。还需要更多高质量的临床研究和动物毒理学实验来验证我们研究结果的可靠性及其潜在机制。
