Yang An-Ming, Chu Pei-Lun, Wang ChiKang, Lin Chien-Yu
Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, 237, Taiwan.
Department of Healthcare Management, Yuanpei University of Medical Technology, Hsinchu, 300, Taiwan.
J Expo Sci Environ Epidemiol. 2024 Mar;34(2):287-293. doi: 10.1038/s41370-023-00594-2. Epub 2023 Sep 6.
Glyphosate, the herbicide with the highest global usage, has been found to have links to neurological impairment in some occupational studies. Neurofilament light chain (NfL) is a protein that is released into the bloodstream following neuroaxonal damage and has emerged as a reliable biomarker for various neurological disorders. However, no research has investigated the potential link between glyphosate exposure and neurological damage or serum NfL levels in the general population.
The objective of this study was to assess the possible correlation between glyphosate exposure and serum NfL levels in a population that is representative of the United States.
We analyzed data from 597 adults (aged ≥20 years) from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) to explore the potential correlation between urinary glyphosate levels and serum NfL levels.
We found a significant positive association between urinary glyphosate levels and serum NfL levels (ß-coefficient = 0.110; S.E. = 0.040; P = 0.015), indicating that higher levels of glyphosate exposure may be linked to higher levels of neuroaxonal damage. Furthermore, when glyphosate levels were divided into quintiles, we observed a significant trend of increasing mean NfL concentrations with increasing quintiles of glyphosate exposure (P for trend = 0.036). Notably, the association was more pronounced in certain subgroups, including those aged ≥40 years, non-Hispanic whites, and those with a BMI between 25 and 30.
This is the first research to suggest an association between glyphosate exposure and biomarkers indicative of neurological damage in general U.S. adults. If the correlation observed is causal, it raises concerns about the potential effects of glyphosate exposure on neurological health among U.S. adults. The study is noteworthy due to its representation of American adults aged 20 and above, as well as the use of reliable and comprehensive data from the NHANES database.
草甘膦是全球使用量最高的除草剂，一些职业研究发现它与神经损伤有关。神经丝轻链（NfL）是一种在神经轴突损伤后释放到血液中的蛋白质，已成为各种神经系统疾病的可靠生物标志物。然而，尚无研究调查草甘膦暴露与普通人群神经损伤或血清NfL水平之间的潜在联系。
本研究的目的是评估在美国具有代表性的人群中，草甘膦暴露与血清NfL水平之间可能存在的相关性。
我们分析了2013 - 2014年国家健康与营养检查调查（NHANES）中597名年龄≥20岁成年人的数据，以探讨尿草甘膦水平与血清NfL水平之间的潜在相关性。
我们发现尿草甘膦水平与血清NfL水平之间存在显著正相关（β系数 = 0.110；标准误 = 0.040；P = 0.015），这表明较高水平的草甘膦暴露可能与较高水平的神经轴突损伤有关。此外，当将草甘膦水平分为五分位数时，我们观察到随着草甘膦暴露五分位数的增加，平均NfL浓度有显著上升趋势（趋势P = 0.036）。值得注意的是，这种关联在某些亚组中更为明显，包括年龄≥40岁的人群、非西班牙裔白人以及体重指数在25至30之间的人群。
这是第一项表明草甘膦暴露与美国普通成年人中指示神经损伤的生物标志物之间存在关联的研究。如果观察到的相关性是因果关系，那么它引发了对草甘膦暴露对美国成年人神经健康潜在影响的担忧。该研究值得关注，因为它代表了20岁及以上的美国成年人，并且使用了NHANES数据库中的可靠且全面的数据。
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