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Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure.

作者信息

Qian Yongbing, Hong Xiaoning, Yu Yang, Du Cong, Li Jing, Yu Jiaying, Xiao Wenjun, Chen Chen, Huang Defa, Zhong Tianyu, Li Jiang, Xiang Xi, Li Zhigang

机构信息

Department of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

出版信息

Clin Transl Med. 2024 Oct;14(10):e70059. doi: 10.1002/ctm2.70059.

DOI:10.1002/ctm2.70059
PMID:39406484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11479749/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/d4f3f163f505/CTM2-14-e70059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/4ce164046b3e/CTM2-14-e70059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/7e66d9df130a/CTM2-14-e70059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/abfd62eada66/CTM2-14-e70059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/d4f3f163f505/CTM2-14-e70059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/4ce164046b3e/CTM2-14-e70059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/7e66d9df130a/CTM2-14-e70059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/abfd62eada66/CTM2-14-e70059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d86/11479749/d4f3f163f505/CTM2-14-e70059-g001.jpg

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Unveiling the mysteries of extrachromosomal circular DNA: from generation to clinical relevance in human cancers and health.

本文引用的文献

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J Extracell Vesicles. 2023 Dec;12(12):e12385. doi: 10.1002/jev2.12385.
2
Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure.乙型肝炎病毒相关慢加急性肝衰竭中与脂质代谢相关的肝内巨噬细胞重编程。
J Transl Med. 2023 Jun 28;21(1):419. doi: 10.1186/s12967-023-04294-1.
3
Extrachromosomal circular DNA: Current status and future prospects.
揭开染色体外环状DNA的奥秘:从产生到在人类癌症与健康中的临床相关性
Mol Cancer. 2024 Dec 20;23(1):276. doi: 10.1186/s12943-024-02187-5.
染色体外环状 DNA:现状与未来展望。
Elife. 2022 Oct 18;11:e81412. doi: 10.7554/eLife.81412.
4
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases.染色体外环状 DNA:生物发生、结构、功能与疾病
Signal Transduct Target Ther. 2022 Oct 2;7(1):342. doi: 10.1038/s41392-022-01176-8.
5
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.急性肝衰竭合并慢性肝病:亚太肝病学会(APASL)的共识推荐意见:更新版。
Hepatol Int. 2019 Jul;13(4):353-390. doi: 10.1007/s12072-019-09946-3. Epub 2019 Jun 6.
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Small extrachromosomal circular DNAs, microDNA, produce short regulatory RNAs that suppress gene expression independent of canonical promoters.小型染色体外环状 DNA(microDNA)产生短的调控 RNA,可独立于典型启动子抑制基因表达。
Nucleic Acids Res. 2019 May 21;47(9):4586-4596. doi: 10.1093/nar/gkz155.
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J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018.
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J Hepatol. 2017 May;66(5):1047-1081. doi: 10.1016/j.jhep.2016.12.003.
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