Wang Zilong, Yu Jiaying, Zhu Wenli, Hong Xiaoning, Xu Zhen, Mao Shuang, Huang Lei, Han Peng, He Chunxiao, Song Changze, Xiang Xi
Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China.
Department of Andrology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China.
Mol Cancer. 2024 Dec 20;23(1):276. doi: 10.1186/s12943-024-02187-5.
Extrachromosomal circular DNAs (eccDNAs) are a type of circular DNAs originating from but independent of chromosomal DNAs. Nowadays, with the rapid development of sequencing and bioinformatics, the accuracy of eccDNAs detection has significantly improved. This advancement has consequently enhanced the feasibility of exploring the biological characteristics and functions of eccDNAs. This review elucidates the potential mechanisms of eccDNA generation, the existing methods for their detection and analysis, and their basic features. Furthermore, it focuses on the biological functions of eccDNAs in regulating gene expression under both physiological and pathological conditions. Additionally, the review summarizes the clinical implications of eccDNAs in human cancers and health.
染色体外环状DNA（eccDNA）是一类起源于染色体DNA但独立于染色体DNA的环状DNA。如今，随着测序技术和生物信息学的快速发展，eccDNA检测的准确性有了显著提高。这一进展相应地提高了探索eccDNA生物学特性和功能的可行性。本文综述阐述了eccDNA产生的潜在机制、现有的检测和分析方法及其基本特征。此外，还重点讨论了eccDNA在生理和病理条件下调节基因表达的生物学功能。此外，本文综述总结了eccDNA在人类癌症和健康方面的临床意义。
