Institut Gustave Roussy, INSERM U1015, Villejuif, France.
Institut Necker Enfants Malades (INEM), INSERM, CNRS, Université Paris Cité, Paris, France.
Results Probl Cell Differ. 2024;74:89-118. doi: 10.1007/978-3-031-65944-7_3.
Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function. However, the exact mechanistic links between macronutrient intake and cellular metabolic shifts are only beginning to be understood. In this chapter, we explore how dietary "macros"-carbohydrates, fats, and amino acids-impact the immunomodulatory activity of macrophages in healthy and inflamed tissues.
髓系细胞，包括单核细胞、巨噬细胞、树突状细胞和多形核细胞，是维持内环境稳态和免疫反应的关键组成部分。在髓系细胞中，巨噬细胞是一种非常多样化的细胞，它既能保护组织功能，又能感知和响应潜在的有害微环境信号。大量研究表明，营养状况和宏量营养素的可用性影响巨噬细胞的特性和功能。然而，宏量营养素摄入与细胞代谢变化之间的确切机制联系才刚刚开始被理解。在本章中，我们探讨了饮食中的“宏量营养素”——碳水化合物、脂肪和氨基酸——如何影响健康和炎症组织中巨噬细胞的免疫调节活性。
