脑内血液出现时间作为氧摄取分数的一种可能指标：一项可行性研究。

Appearance time of blood in the brain as a possible indicator of oxygen extraction fraction: a feasibility study.

作者信息

Murao Mitsumasa, Kudomi Nobuyuki, Mitamura Katsuya, Norikane Takashi, Manabe Yuri, Maeda Yukito, Yamamoto Yuka, Hatakeyama Tetsuhiro, Nishiyama Yoshihiro

机构信息

Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.

Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan.

出版信息

EJNMMI Res. 2024 Oct 16;14(1):97. doi: 10.1186/s13550-024-01160-z.

BACKGROUND

Imaging examination of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen is crucial for understanding the normal functioning and pathophysiology of the brain. A recently developed method estimates the appearance time of cerebral blood (ATB) pixel-wise from the imaging examination of CBF alone. In this study, we aimed to test the potential of ATB as an indicator of OEF.

RESULTS

We retrospectively reviewed patients (n = 62) with suspected cerebrovascular disorders including steno-occlusive disease who underwent positron emission tomography (PET) with O-labelled tracers. Regarding the generated OEF and ATB images, a visual assessment was performed to test the consistency of the elevated OEF and delayed ATB. The OEF and ATB values and the absolute differences between their ipsilateral and contralateral sides were extracted and obtained for the entire hemisphere and the middle, anterior, and posterior cerebral arterial regions. Consistency was observed in 52 PET scans (83.9%) in visual assessment. The OEF and ATB values were moderately correlated (r = 0.553, p < 0.001), and the differences between their ipsilateral and contralateral sides were weakly correlated (r = 0.276, p < 0.001).

CONCLUSION

Our results indicate the potential of ATB as an indicator of OEF.

背景

脑血流量（CBF）、氧摄取分数（OEF）和氧代谢率的成像检查对于理解大脑的正常功能和病理生理学至关重要。最近开发的一种方法仅通过CBF的成像检查逐像素估计脑血出现时间（ATB）。在本研究中，我们旨在测试ATB作为OEF指标的潜力。

结果

我们回顾性分析了62例疑似脑血管疾病（包括狭窄闭塞性疾病）患者，这些患者接受了用氧标记示踪剂的正电子发射断层扫描（PET）。对于生成的OEF和ATB图像，进行了视觉评估以测试OEF升高和ATB延迟的一致性。提取并获得了整个半球以及大脑中动脉、前动脉和后动脉区域的OEF和ATB值及其同侧和对侧之间的绝对差值。在视觉评估中，52次PET扫描（83.9%）观察到一致性。OEF和ATB值呈中度相关（r = 0.553，p < 0.001），其同侧和对侧之间的差值呈弱相关（r = 0.276，p < 0.001）。