• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

改变环结构：手性3-氨基-1-氮杂环在手性[(η-CMe)RhCl]、[(η-CMe)IrCl]和[Ru(η-对异丙基苯)Cl]配合物中杂环大小对立体选择性的影响

Ringing the Changes: Effects of Heterocyclic Ring Size on Stereoselectivity in [(η-CMe)RhCl], [(η-CMe)IrCl] and [Ru(η-cymene)Cl] Complexes of Chiral 3-Amino-1-Azacycles.

作者信息

Vladimirov Vladimir Y, Charrier-Chardin Matheo, Kariuki Benson M, Ward Benjamin D, Newman Paul D

机构信息

School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK.

出版信息

Molecules. 2024 Sep 30;29(19):4659. doi: 10.3390/molecules29194659.

DOI:10.3390/molecules29194659
PMID:39407586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11478173/
Abstract

Ring size-dependent diastereoselective coordination of unsymmetrical diamines containing one azacyclic nitrogen and one exocyclic nitrogen to [(η-CMe)MCl] cores where M = Rh, Ir and [Ru(η-cymene)Cl] is reported herein. Total stereoselectivity was observed with the six- and seven-membered azacycles, whereas the five-derivative proved poorly selective. All complexes were active for transfer hydrogenation but showed no enantioselectivity with prochiral ketones.

摘要

本文报道了含一个氮杂环氮原子和一个环外氮原子的不对称二胺与[(η-CMe)MCl]核（其中M = Rh、Ir）以及[Ru(η-对异丙基苯)Cl]的环尺寸依赖性非对映选择性配位。对于六元环和七元氮杂环观察到了完全的立体选择性，而五元衍生物的选择性较差。所有配合物对转移氢化反应均有活性，但对手性酮没有对映选择性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/b1049b8b8b33/molecules-29-04659-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/b3a0362d9322/molecules-29-04659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/89ebfdbe91e7/molecules-29-04659-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/ea50b46b0ab0/molecules-29-04659-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/18df0b647807/molecules-29-04659-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/30b5cb71db2a/molecules-29-04659-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/56f75912bf73/molecules-29-04659-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/861f07bedf56/molecules-29-04659-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/b1049b8b8b33/molecules-29-04659-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/b3a0362d9322/molecules-29-04659-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/89ebfdbe91e7/molecules-29-04659-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/ea50b46b0ab0/molecules-29-04659-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/18df0b647807/molecules-29-04659-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/30b5cb71db2a/molecules-29-04659-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/56f75912bf73/molecules-29-04659-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/861f07bedf56/molecules-29-04659-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c28/11478173/b1049b8b8b33/molecules-29-04659-g008.jpg

相似文献

1
Ringing the Changes: Effects of Heterocyclic Ring Size on Stereoselectivity in [(η-CMe)RhCl], [(η-CMe)IrCl] and [Ru(η-cymene)Cl] Complexes of Chiral 3-Amino-1-Azacycles.改变环结构：手性3-氨基-1-氮杂环在手性[(η-CMe)RhCl]、[(η-CMe)IrCl]和[Ru(η-对异丙基苯)Cl]配合物中杂环大小对立体选择性的影响
Molecules. 2024 Sep 30;29(19):4659. doi: 10.3390/molecules29194659.
2
Hydroxymethylpyridine containing half-sandwich complexes of Rh(III), Ir(III) or Ru(II).含有铑（III）、铱（III）或钌（II）的半夹心配合物的羟甲基吡啶。
Dalton Trans. 2014 Nov 7;43(41):15546-59. doi: 10.1039/c4dt02171a.
3
Half-sandwich complexes of rhodium containing cysteine-derived ligands.含半胱氨酸衍生配体的铑半夹心配合物。
Dalton Trans. 2016 Sep 28;45(36):14203-15. doi: 10.1039/c6dt02411d. Epub 2016 Aug 17.
4
Comparative solution equilibrium studies of antitumor ruthenium(η-p-cymene) and rhodium(η-CMe) complexes of 8-hydroxyquinolines.抗肿瘤钌(η-p-环戊二烯)和铑(η-CMe)配合物的 8-羟基喹啉的比较溶液平衡研究。
Dalton Trans. 2017 Mar 27;46(13):4382-4396. doi: 10.1039/c7dt00439g.
5
Half-sandwich complexes of iridium and ruthenium containing cysteine-derived ligands.含半三明治型铱和钌配合物的半三明治型铱和钌配合物，含有半胱氨酸衍生配体。
Dalton Trans. 2017 Jan 17;46(3):962-976. doi: 10.1039/c6dt04341k.
6
Organometallic Ru(II), Rh(III) and Re(I) complexes of sterane-based bidentate ligands: synthesis, solution speciation, interaction with biomolecules and anticancer activity.甾烷双齿配体的金属有机 Ru(II)、Rh(III) 和 Re(I) 配合物：合成、溶液形态、与生物分子相互作用和抗癌活性。
Dalton Trans. 2024 Mar 12;53(11):4984-5000. doi: 10.1039/d3dt04138g.
7
Coordinatively diverse ortho-phosphinoaniline complexes of ruthenium and isolation of a putative intermediate in ketone transfer hydrogenation catalysis.钌的配位多样性邻膦苯胺配合物及酮转移加氢催化中假定中间体的分离。
Inorg Chem. 2010 May 3;49(9):4288-300. doi: 10.1021/ic100165t.
8
8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules.8-羟基喹啉-氨基酸杂合体及其半三明治 Rh 和 Ru 配合物的合成、抗癌活性、溶液化学及与生物分子的相互作用。
Int J Mol Sci. 2021 Oct 19;22(20):11281. doi: 10.3390/ijms222011281.
9
Half-sandwich complexes of Ir(iii), Rh(iii) and Ru(ii) with the MaxPhos ligand: metal centred chirality and cyclometallation.铱（III）、铑（III）和钌（II）与MaxPhos配体形成的半夹心配合物：金属中心手性和环金属化作用
Dalton Trans. 2017 Nov 21;46(45):15865-15874. doi: 10.1039/c7dt03327c.
10
Studies of the synthesis and thermochemistry of coordinatively unsaturated chelate complexes (eta 5-C5Me5)IrL2 (L2 = TsNCH2CH2NTs, TsNCH2CO2, CO2CO2).
Inorg Chem. 2000 Jun 12;39(12):2493-9. doi: 10.1021/ic990870l.

本文引用的文献

1
Best-Practice DFT Protocols for Basic Molecular Computational Chemistry.基础分子计算化学的最佳实践密度泛函理论协议
Angew Chem Int Ed Engl. 2022 Oct 17;61(42):e202205735. doi: 10.1002/anie.202205735. Epub 2022 Sep 14.
2
Heterocycle-containing Noyori-Ikariya catalysts for asymmetric transfer hydrogenation of ketones.含杂环的 Noyori-Ikariya 催化剂在酮的不对称转移氢化中的应用。
Dalton Trans. 2022 Sep 13;51(35):13462-13469. doi: 10.1039/d2dt02411j.
3
A trust-region augmented Hessian implementation for restricted and unrestricted Hartree-Fock and Kohn-Sham methods.
一种用于受限和无限制哈特里-福克方法及科恩-沙姆方法的信赖域增强海森矩阵实现。
J Chem Phys. 2021 Apr 28;154(16):164104. doi: 10.1063/5.0040798.
4
rSCAN-3c: A "Swiss army knife" composite electronic-structure method.rSCAN-3c：一种“瑞士军刀”式的复合电子结构方法。
J Chem Phys. 2021 Feb 14;154(6):064103. doi: 10.1063/5.0040021.
5
Launching Werner Complexes into the Modern Era of Catalytic Enantioselective Organic Synthesis.将 Werner 配合物推向催化对映选择性有机合成的现代时代。
Acc Chem Res. 2020 Oct 20;53(10):2299-2313. doi: 10.1021/acs.accounts.0c00410. Epub 2020 Sep 4.
6
Accurate and Numerically Efficient rSCAN Meta-Generalized Gradient Approximation.精确且数值高效的rSCAN元广义梯度近似
J Phys Chem Lett. 2020 Oct 1;11(19):8208-8215. doi: 10.1021/acs.jpclett.0c02405. Epub 2020 Sep 16.
7
Escaping from Flatland: Stereoconvergent Synthesis of Three-Dimensional Scaffolds via Ruthenium(II)-Catalyzed Noyori-Ikariya Transfer Hydrogenation.逃离平面国：通过钌（II）催化的 Noyori-Ikariya 转移氢化实现三维支架的立体协同合成。
Chemistry. 2021 Jan 4;27(1):39-53. doi: 10.1002/chem.202002779. Epub 2020 Oct 22.
8
Asymmetric catalysis with a chiral-at-osmium complex.使用锇手性配合物的不对称催化。
Chem Commun (Camb). 2020 Jul 14;56(56):7714-7717. doi: 10.1039/d0cc03280h.
9
Atroposelective Synthesis of Axially Chiral N-Arylpyrroles by Chiral-at-Rhodium Catalysis.通过铑手性催化实现轴手性N-芳基吡咯的对映选择性合成。
Angew Chem Int Ed Engl. 2020 Aug 3;59(32):13552-13556. doi: 10.1002/anie.202004799. Epub 2020 Jun 3.
10
Preparation of chiral-at-metal catalysts and their use in asymmetric photoredox chemistry.手性金属催化剂的制备及其在手性光氧化还原化学中的应用。
Nat Protoc. 2018 Apr;13(4):605-632. doi: 10.1038/nprot.2017.138. Epub 2018 Mar 1.