诊断轻链型和转甲状腺素蛋白淀粉样变心肌病：多学科方法

Diagnosing AL and ATTR Amyloid Cardiomyopathy: A Multidisciplinary Approach.

作者信息

Aus dem Siepen Fabian, Hansen Timon

机构信息

Department of Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

Onkologicum HOPA, 22767 Hamburg, Germany.

出版信息

J Clin Med. 2024 Oct 1;13(19):5873. doi: 10.3390/jcm13195873.

DOI:10.3390/jcm13195873

PMID:39407933

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11477302/

Abstract

Amyloidosis with cardiac involvement is a fatal disease leading to progressive heart failure. The most common forms of amyloidosis with cardiac involvement are light chain (AL) and transthyretin (ATTR) amyloidosis. To allow effective specific treatment for both forms, precise and early diagnosis is important. This review focuses on diagnostic approaches for AL and ATTR amyloidosis with cardiac involvement, including different strategies, the role of imaging and biomarkers and possible pitfalls.

摘要

伴有心脏受累的淀粉样变性是一种导致进行性心力衰竭的致命疾病。伴有心脏受累的淀粉样变性最常见的形式是轻链（AL）和转甲状腺素蛋白（ATTR）淀粉样变性。为了对这两种形式进行有效的特异性治疗，精确的早期诊断很重要。本综述重点关注伴有心脏受累的AL和ATTR淀粉样变性的诊断方法，包括不同策略、影像学和生物标志物的作用以及可能存在的陷阱。