Fabara-Rodríguez Anthia Cristina, García-Bravo Cristina, García-Bravo Sara, Quirosa-Galán Isabel, Rodríguez-Pérez Mª Pilar, Pérez-Corrales Jorge, Fernández-Gómez Gemma, Donovan Madeleine, Huertas-Hoyas Elisabet
Geriasa Brunete, Nursing Home, 28690 Brunete, Spain.
Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Research Group of Humanities and Qualitative Research in Health Science (Hum&QRinHS), 28922 Alcorcón, Spain.
J Clin Med. 2024 Oct 8;13(19):5982. doi: 10.3390/jcm13195982.
(1) Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and functional impairment. The NeuronUP platform is a computer program whose main function is cognitive stimulation through three types of activities that change so that the user does not manage to learn it. This program provides opportunities to work on various domains, including activities of daily living (ADLs), social skills, and cognitive functions. The main objective of this randomized clinical trial was to assess the impact of integrating the NeuronUP platform with conventional occupational therapy to enhance or maintain cognitive, perceptual, and quality of life (QoL) abilities in people with AD compared to a control group. (2) A randomized, single-blind clinical trial was conducted. The sample was randomized using a software program, OxMar, which allowed the separation of the sample into a control group (CG) that received their conventional occupational therapy sessions and an experimental group (EG) that received therapy with NeuronUP, in addition to their conventional occupational therapy sessions. An eighteen-week intervention was conducted. (3) The study included 20 participants, and significant differences were observed in most variables analyzed, indicating improvements after the intervention, particularly in measures of QoL and cognitive status. (4) Our findings demonstrate that an eighteen-week experimental protocol, incorporating the NeuronUP platform alongside conventional occupational therapy, led to improvements in cognitive status and QoL in older adults with AD. Thus, integrating the NeuronUP platform as a complementary tool to occupational therapy can be a valuable resource for enhancing the QoL of individuals with AD. However, due to the small sample size, further studies are needed to corroborate these findings.
（1）阿尔茨海默病（AD）是一种以认知能力下降和功能障碍为特征的进行性神经退行性疾病。NeuronUP平台是一款计算机程序，其主要功能是通过三种不断变化的活动来进行认知刺激，从而使用户难以掌握。该程序提供了在多个领域开展训练的机会，包括日常生活活动（ADL）、社交技能和认知功能。这项随机临床试验的主要目的是评估将NeuronUP平台与传统职业治疗相结合，与对照组相比，对AD患者的认知、感知和生活质量（QoL）能力的增强或维持作用。（2）进行了一项随机、单盲临床试验。使用软件程序OxMar对样本进行随机分组，该程序将样本分为接受传统职业治疗课程的对照组（CG）和除接受传统职业治疗课程外还接受NeuronUP治疗的实验组（EG）。进行了为期18周的干预。（3）该研究纳入了20名参与者，在分析的大多数变量中观察到显著差异，表明干预后有改善，特别是在生活质量和认知状态的测量方面。（4）我们的研究结果表明，一项为期18周的实验方案，将NeuronUP平台与传统职业治疗相结合，使患有AD的老年人的认知状态和生活质量得到改善。因此，将NeuronUP平台作为职业治疗的辅助工具，可以成为提高AD患者生活质量的宝贵资源。然而，由于样本量较小，需要进一步研究来证实这些发现。
