Soldevila-Domenech Natalia, De Toma Ilario, Forcano Laura, Diaz-Pellicer Patrícia, Cuenca-Royo Aida, Fagundo Beatriz, Lorenzo Thais, Gomis-Gonzalez Maria, Sánchez-Benavides Gonzalo, Fauria Karine, Sastre Carolina, Fernandez De Piérola Íñigo, Molinuevo José Luis, Verdejo-Garcia Antonio, de la Torre Rafael
Neurosciences Research Programme, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.
iScience. 2023 May 16;26(6):106886. doi: 10.1016/j.isci.2023.106886. eCollection 2023 Jun 16.
Traditional neuropsychological tests accurately describe the current cognitive state but fall short to characterize cognitive change over multiple short time periods. We present an innovative approach to remote monitoring of executive functions on a monthly basis, which leverages the performance indicators from self-administered computerized cognitive training games (NUP-EXE). We evaluated the measurement properties of NUP-EXE in N = 56 individuals (59% women, 60-80 years) at increased risk of Alzheimer's disease (-ϵ4 carriers with subjective cognitive decline) who completed a 12-month multimodal intervention for preventing cognitive decline. NUP-EXE presented good psychometric properties and greater sensitivity to change than traditional tests. Improvements in NUP-EXE correlated with improvements in functionality and were affected by participants' age and gender. This novel data collection methodology is expected to allow a more accurate characterization of an individual's response to a cognitive decline preventive intervention and to inform development of outcome measures for a new generation of intervention trials.
传统的神经心理学测试能够准确描述当前的认知状态，但在刻画多个短时间段内的认知变化方面存在不足。我们提出了一种创新方法，可每月对执行功能进行远程监测，该方法利用了自我管理的计算机化认知训练游戏（NUP-EXE）的性能指标。我们评估了NUP-EXE在56名个体（59%为女性，年龄在60至80岁之间）中的测量属性，这些个体患阿尔茨海默病的风险增加（携带-ϵ4且有主观认知衰退），他们完成了一项为期12个月的预防认知衰退的多模式干预。NUP-EXE表现出良好的心理测量属性，并且比传统测试对变化更敏感。NUP-EXE的改善与功能的改善相关，并且受参与者年龄和性别的影响。这种新颖的数据收集方法有望更准确地刻画个体对认知衰退预防干预的反应，并为新一代干预试验的结果测量发展提供信息。
