酒精对治疗剂量对乙酰氨基酚的致死性增强作用。
Lethal enhancement of therapeutic doses of acetaminophen by alcohol.
作者信息
Lesser P B, Vietti M M, Clark W D
出版信息
Dig Dis Sci. 1986 Jan;31(1):103-5. doi: 10.1007/BF01347918.
PMID:3940815
Abstract
A 47-year-old man undergoing supervised alcohol detoxification developed severe liver disease after receiving small doses of acetaminophen. Autopsy revealed extensive hepatic necrosis. Proposed mechanisms for alcohol potentiation of acetaminophen hepatotoxicity are described. We feel acetaminophen should not be routinely used for patients with active alcoholism unless its safety can be established.
摘要
一名47岁正在接受戒酒治疗的男性在服用小剂量对乙酰氨基酚后出现严重肝病。尸检显示广泛的肝坏死。文中描述了酒精增强对乙酰氨基酚肝毒性的可能机制。我们认为，除非能确定其安全性，否则对乙酰氨基酚不应常规用于患有酒精中毒的患者。
Zotero 插件