Oncology Unit, "Andrea Tortora" Hospital, ASL Salerno, 84016 Pagani, Italy.
Associazione O.R.A. ETS-Oncology Research Assistance, 84134 Salerno, Italy.
Nutrients. 2024 Sep 29;16(19):3302. doi: 10.3390/nu16193302.
Oxidative stress has emerged as a key contributor to numerous NCDs (non-communicable diseases), including cardiovascular diseases, cancer, and diabetes. This study aims to explore the potential of targeted interventions to mitigate oxidative stress as part of a primary prevention strategy.
The study included 32 healthy participants (11 men, 21 women) aged 45-65 who completed both the initial and follow-up assessments of the Healthy Days Initiative, a community-based wellness program organized by the non-profit Associazione O.R.A. ETS. Through blood analysis, vital sign assessment, lifestyle questionnaires, and individualized recommendations, participants received guidance on improving their health and reducing disease risk. The initiative also offered the opportunity for participants to consume a flavonoid supplement containing quercitrin, rutin, and hesperidin, with the goal of reducing oxidative stress. Participants who opted for supplementation were instructed to take 1-2 tablets daily for two weeks. Data collected included demographic information, anthropometric measurements, vital signs, dietary and lifestyle habits, medical history, WHO-5 Well-Being Index scores, and blood parameters.
Significant reductions were observed in glucose levels (from 82 to 74.5 mg/dL), reactive oxygen metabolites (d-ROMs) (from 394.5 to 365.5 U.CARR), and systolic blood pressure (from 133 to 122 mmHg) after the two-week flavonoid intervention. Most participants (26/31) reported no side effects, and the majority (30/31) expressed a willingness to continue using a product combination of quercitrin, rutin, and hesperidin or a similar product long-term.
While limited in scope and duration, the PREVES-FLAVON study contributes valuable insights to the growing body of evidence suggesting that flavonoid supplementation may play a significant role in reducing risk factors associated with NCDs in primary prevention settings. By targeting novel risk factors such as oxidative stress, this intervention holds promise for mitigating the global burden of NCDs and promoting healthy aging.
氧化应激已成为许多非传染性疾病（NCDs）的关键致病因素，包括心血管疾病、癌症和糖尿病。本研究旨在探讨靶向干预减轻氧化应激的潜力，作为初级预防策略的一部分。
本研究纳入了 32 名年龄在 45-65 岁的健康参与者（11 名男性，21 名女性），他们均完成了基于社区的健康促进计划——“健康日倡议”的初始和随访评估，该计划由非营利组织 Associazione O.R.A. ETS 组织。通过血液分析、生命体征评估、生活方式问卷和个体化建议，参与者获得了改善健康和降低疾病风险的指导。该倡议还为参与者提供了消费含有槲皮素、芦丁和橙皮苷的类黄酮补充剂的机会，以减轻氧化应激。选择补充剂的参与者被指示每天服用 1-2 片，持续两周。收集的数据包括人口统计学信息、人体测量学测量、生命体征、饮食和生活方式习惯、病史、WHO-5 幸福感指数评分和血液参数。
在接受两周的类黄酮干预后，参与者的血糖水平（从 82 降至 74.5mg/dL）、活性氧代谢物（d-ROMs）（从 394.5 降至 365.5U.CARR）和收缩压（从 133 降至 122mmHg）显著降低。大多数参与者（26/31）报告没有副作用，大多数参与者（30/31）表示愿意长期继续使用槲皮素、芦丁和橙皮苷的产品组合或类似产品。
尽管本研究范围和持续时间有限，但 PREVES-FLAVON 研究为越来越多的证据提供了有价值的见解，表明类黄酮补充剂可能在降低初级预防环境中非传染性疾病相关风险因素方面发挥重要作用。通过靶向氧化应激等新的风险因素，这种干预措施有望减轻非传染性疾病的全球负担，促进健康老龄化。
