Department of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdansk, 80-214 Gdansk, Poland.
Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland.
Nutrients. 2024 Sep 30;16(19):3319. doi: 10.3390/nu16193319.
Epidemiologic evidence has demonstrated the prevalence of metabolic disorders and increased cardiovascular risk related to lipid metabolism disorders in kidney transplant recipients. Therefore, it is of great importance to understand lipid alterations and to look for ways to reduce cardiovascular risk in this patient group. Our study included 25 patients with chronic kidney disease undergoing kidney transplantation (KTx). Three blood samples were taken from each patient: before KTx, 3 months after KTx and 6-12 months after KTx. A series of biochemical blood tests and a detailed analysis of the serum fatty acid profile were performed. In our previous study, the effects of kidney transplantation on serum fatty acid (FA) profile 3 months after the procedure were investigated. The current study shows the longer-term (6-12 months) effects of the procedure on the serum FA profile. We found that although -3 polyunsaturated FA levels started to decrease 3 months after surgery, they normalized over a longer period of time (6-12 months). Furthermore, we observed a strong decrease in ultra-long-chain FAs and an increase in odd-chain FAs over a longer time after kidney transplantation. All of the above FAs may have an important impact on human health, including inflammation, cardiovascular risk or cancer risk. The changes in serum FA profiles after kidney transplantation are a dynamic process and that more detailed studies could provide an accurate indication for supplementation with some FAs or diet modification.
流行病学证据表明，肾移植受者存在代谢紊乱和与脂质代谢紊乱相关的心血管风险增加。因此，了解脂质变化并寻找降低该患者群体心血管风险的方法非常重要。
我们的研究纳入了 25 名接受肾移植（KTx）的慢性肾脏病患者。从每位患者中采集了 3 份血样：KTx 前、KTx 后 3 个月和 KTx 后 6-12 个月。进行了一系列生化血液检查和血清脂肪酸谱的详细分析。
在我们之前的研究中，研究了肾移植对术后 3 个月血清脂肪酸（FA）谱的影响。本研究显示了该手术对血清 FA 谱的更长时间（6-12 个月）影响。我们发现，尽管手术后 3 个月 -3 多不饱和脂肪酸水平开始下降，但它们在更长的时间内（6-12 个月）恢复正常。此外，我们观察到在肾移植后更长时间内超长链 FAs 和奇数链 FAs 的强烈减少。所有上述 FAs 可能对人类健康有重要影响，包括炎症、心血管风险或癌症风险。
肾移植后血清 FA 谱的变化是一个动态过程，更详细的研究可以为某些 FA 的补充或饮食调整提供准确的指示。
