Gandhewar Nivedita, Shende Pravin
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India.
National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar (Mohali), Panjab, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 23. doi: 10.1007/s00210-025-04374-7.
The study meant to advance a wound healing film comprised of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), methyl red and gold nanoparticles (AuNPs), which can facilitate wound healing process and detect the healing process through a color change. The main research question was how to optimize the formulation for superior wound healing capabilities. Six formulations (TF-1 to TF-6) were prepared and evaluated based on moisture absorption rate, folding endurance, color-changing efficacy, in vitro release and in vivo studies. The optimized formulation, TF-4, showed a tensile strength of 2.112 ± 0.622 kg/mm, a moisture transfer rate of 5.5 ± 0.22%, folding endurance greater than 280, in vitro release of 75.19 ± 0.013% and color alteration from yellow to light orange upon pH change and in vivo studies showed no skin irritation. TF-4 also promoted faster wound healing process with earlier wound closure compared to other groups. The conclusion is that the optimized formulation, TF-4, demonstrated superior wound healing process capabilities without any negative skin effects, showing great potential as an effective wound-care method.
该研究旨在开发一种由聚乙烯醇（PVA）、聚乙烯吡咯烷酮（PVP）、甲基红和金纳米颗粒（AuNPs）组成的伤口愈合薄膜，其可促进伤口愈合过程并通过颜色变化检测愈合过程。主要研究问题是如何优化配方以获得卓越的伤口愈合能力。制备了六种配方（TF-1至TF-6），并基于吸湿率、耐折性、变色效果、体外释放和体内研究进行评估。优化后的配方TF-4的拉伸强度为2.112±0.622 kg/mm，水分转移率为5.5±0.22%，耐折性大于280，体外释放率为75.19±0.013%，pH值变化时颜色从黄色变为浅橙色，体内研究表明无皮肤刺激性。与其他组相比，TF-4还促进了更快的伤口愈合过程，伤口闭合更早。结论是，优化后的配方TF-4表现出卓越的伤口愈合能力且无任何负面皮肤影响，作为一种有效的伤口护理方法具有巨大潜力。
