Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Department of Biotechnology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Int J Mol Sci. 2024 Sep 29;25(19):10496. doi: 10.3390/ijms251910496.
C10orf90, a tumor suppressor, can inhibit the occurrence and development of tumors. Therefore, we investigated the gene function of in various tumors using multiple pan-cancer datasets. Pan-cancer analysis results reveal that the expression levels of vary across different tumors and hold significant value in the clinical diagnosis and prognosis of patients with various tumors. In some cancers, the expression level of is correlated with CNV, DNA methylation, immune subtypes, immune cell infiltration, and drug sensitivity in the tumors. In particular, in COAD, the gene is implicated in multiple processes associated with COAD. Cell experiments demonstrate that suppresses the proliferation and migration of colon cancer cells while promoting apoptosis. In summary, plays a role in the onset and progression of various cancers and could potentially serve as an effective diagnostic and prognostic marker for cancer patients. Notably, in COAD, inhibits the proliferation and migration of colon cancer cells, induces apoptosis, and is linked to the advancement of colon cancer.
C10orf90 是一种肿瘤抑制因子，可以抑制肿瘤的发生和发展。因此，我们使用多个泛癌数据集研究了 C10orf90 在各种肿瘤中的基因功能。泛癌分析结果表明，C10orf90 在不同肿瘤中的表达水平存在差异，对不同肿瘤患者的临床诊断和预后具有重要意义。在某些癌症中，C10orf90 的表达水平与肿瘤的 CNV、DNA 甲基化、免疫亚型、免疫细胞浸润和药物敏感性相关。特别是在 COAD 中，C10orf90 基因与 COAD 相关的多个过程有关。细胞实验表明，C10orf90 抑制结肠癌细胞的增殖和迁移，同时促进细胞凋亡。综上所述，C10orf90 在多种癌症的发生和发展中发挥作用，可能成为癌症患者有效诊断和预后的标志物。值得注意的是，在 COAD 中，C10orf90 抑制结肠癌细胞的增殖和迁移，诱导细胞凋亡，并与结肠癌细胞的进展有关。
