The Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China.
Int J Mol Sci. 2024 Oct 6;25(19):10760. doi: 10.3390/ijms251910760.
Necroptosis is a type of regulated cell death (RCD) that is triggered by changes in the extracellular or intracellular milieu that are picked up by certain death receptors. Thanks to its potent capacity to induce immunological responses and overcome apoptotic resistance, it has garnered significant attention as a potential cancer treatment. Basic information for the creation of nano-biomedical treatments is provided by studies on the mechanisms underlying tumor necroptosis. Receptor-interacting protein kinase 1 (RIPK1)-RIPK3-mediated necroptosis, Toll-like receptor domain-containing adapter-inducing interferon (IFN)-β (TRIF)-RIPK3-mediated necroptosis, Z-DNA-binding protein 1 (ZBP1)-RIPK3-mediated necroptosis, and IFNR-mediated necroptosis are the four signaling pathways that collectively account for triggered necroptosis in this review. Necroptosis has garnered significant interest as a possible cancer treatment strategy because, in contrast to apoptosis, it elicits immunological responses that are relevant to therapy. Thus, a thorough discussion is held on the connections between tumor cell necroptosis and the immune environment, cancer immunosurveillance, and cells such as dendritic cells (DCs), cytotoxic T cells, natural killer (NK) cells, natural killer T (NKT) cells, and their respective cytokines. Lastly, a summary of the most recent nanomedicines that cause necroptosis in order to cause immunogenic cell death is provided in order to emphasize their promise for cancer immunotherapy.
细胞坏死是一种受细胞外或细胞内环境变化触发的调控性细胞死亡（RCD），这些变化被特定的死亡受体识别。由于其能够有效诱导免疫反应并克服凋亡抵抗，它作为一种潜在的癌症治疗方法引起了广泛关注。肿瘤细胞坏死的机制研究为纳米生物医学治疗的创建提供了基础信息。受体相互作用蛋白激酶 1（RIPK1）-RIPK3 介导的细胞坏死、Toll 样受体结构域包含衔接诱导干扰素（IFN）-β（TRIF）-RIPK3 介导的细胞坏死、Z-DNA 结合蛋白 1（ZBP1）-RIPK3 介导的细胞坏死和 IFNR 介导的细胞坏死是本综述中共同导致触发细胞坏死的四种信号通路。与凋亡不同，细胞坏死引发与治疗相关的免疫反应，因此作为一种可能的癌症治疗策略引起了广泛关注。因此，本文深入讨论了肿瘤细胞坏死与免疫环境、癌症免疫监视以及树突状细胞（DC）、细胞毒性 T 细胞、自然杀伤（NK）细胞、自然杀伤 T（NKT）细胞及其各自细胞因子之间的联系。最后，总结了最近能够引发细胞坏死以引起免疫原性细胞死亡的纳米药物，以强调它们在癌症免疫治疗中的应用前景。
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