Sultan Sheriff D
Horm Res. 1986;23(1):60-3. doi: 10.1159/000180288.
Prolactin administration for 7 day to pubertal rats resulted in marked depletion of total lipids, phospholipids and particularly phosphatidyl choline and phosphatidyl ethanolamine. There was a concomitant increase in total cholesterol and cholesterol ester with a fall in free cholesterol. The increase in total cholesterol in the testis of prolactin-treated animals appears not to be due to its increased synthesis, as the hormonal treatment had no significant effect on HMG-Co A reductase, the rate limiting enzyme of sterol synthesis. Prolactin also had no significant effect on the enzymes glucose-6-phosphate dehydrogenase, malic- and isocitrate dehydrogenases reported to generate NADPH required for active steroidogenesis. Thus, it appears that the fall observed in testicular phospholipids and free cholesterol with concurrent increases in total cholesterol and cholesterol ester after prolactin administration is not due to prolactin's effect directly on testicular lipid metabolism in pubertal rats.
对青春期大鼠连续7天给予催乳素，导致总脂质、磷脂尤其是磷脂酰胆碱和磷脂酰乙醇胺显著减少。同时，总胆固醇和胆固醇酯增加，游离胆固醇减少。催乳素处理动物的睾丸中总胆固醇的增加似乎并非由于其合成增加，因为激素处理对HMG-Co A还原酶（固醇合成的限速酶）没有显著影响。催乳素对据报道产生活性类固醇生成所需NADPH的葡萄糖-6-磷酸脱氢酶、苹果酸脱氢酶和异柠檬酸脱氢酶也没有显著影响。因此，催乳素给药后观察到的睾丸磷脂和游离胆固醇下降，同时总胆固醇和胆固醇酯增加，似乎不是由于催乳素直接对青春期大鼠睾丸脂质代谢的影响。
