Hong Yifeng, Tan Cheng, He Xiaoyan, Wu Dan, Zhang Yuxing, Song Changxu, Wu Zhenfang
College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
State Key Laboratory of Swine and Poultry Breeding Industry, Guangzhou 510640, China.
Animals (Basel). 2024 Oct 6;14(19):2874. doi: 10.3390/ani14192874.
(1) Background: Reproductive performance is crucial for the pork industry's success. The Large White pig is central to this, yet the genetic factors influencing its reproductive traits are not well understood, highlighting the need for further research. (2) Methods: This study utilized Genome-Wide Association Studies to explore the genetic basis of reproductive traits in the Large White pig. We collected data from 2237 Large White sows across four breeding herds in southern China, focusing on eight reproductive traits. Statistical analyses included principal component analysis, linkage disequilibrium analysis, and univariate linear mixed models to identify significant single-nucleotide polymorphisms and candidate genes. (3) Results: Forty-five significantly related SNPs and 17 potential candidate genes associated with litter traits were identified. Individuals with the TT genotype at SNP rs341909772 showed an increase of 1.24 in the number of piglets born alive (NBA) and 1.25 in the number of healthy births (NHBs) compared with those with the CC genotype. (4) Conclusions: The SNPs and genes identified in this study offer insights into the genetics of reproductive traits in the Large White pig, potentially guiding the development of breeding strategies to improve litter size.
(1) 背景：繁殖性能对养猪业的成功至关重要。大白猪在其中起着核心作用，然而影响其繁殖性状的遗传因素尚未得到充分了解，这凸显了进一步研究的必要性。(2) 方法：本研究利用全基因组关联研究来探索大白猪繁殖性状的遗传基础。我们收集了来自中国南方四个育种群体的2237头大白母猪的数据，重点关注八个繁殖性状。统计分析包括主成分分析、连锁不平衡分析和单变量线性混合模型，以确定显著的单核苷酸多态性和候选基因。(3) 结果：鉴定出45个与产仔性状显著相关的单核苷酸多态性和17个潜在候选基因。与CC基因型个体相比，SNP rs341909772处TT基因型个体的产活仔数（NBA）增加了1.24，健康出生数（NHBs）增加了1.25。(4) 结论：本研究中鉴定出的单核苷酸多态性和基因有助于深入了解大白猪繁殖性状的遗传学，可能为制定提高产仔数的育种策略提供指导。
