致病和非致病耐格里属原虫的迁移模式
Migration patterns of pathogenic and nonpathogenic Naegleria spp.
作者信息
Thong Y H, Ferrante A
出版信息
Infect Immun. 1986 Jan;51(1):177-80. doi: 10.1128/iai.51.1.177-180.1986.
Abstract
Four species of Naegleria were tested for their ability to migrate under agarose. Pathogenic N. fowleri strains exhibited rapid locomotion at 37 degrees C. Environmental isolates of N. fowleri moved faster than clinical isolates which had been kept in axenic culture for longer periods, and this result was confirmed by using the 84-2205-7 strain kept in axenic culture for 1 or 5 months. Nonpathogenic N. gruberi strains migrated actively at 28 degrees C but not at 37 degrees C; moreover, even at 28 degrees C, active amoebae constituted only a small proportion of the whole. The temperature-tolerant, nonpathogenic species N. lovaniensis moved more slowly than N. fowleri at 37 degrees C. In contrast, N. australiensis, which is temperature tolerant as well as pathogenic for mice, migrated at a rate comparable to that of N. fowleri. There appears to be a direct correlation between the locomotive ability of free-living amoebae and their pathogenic potential.
摘要
对四种耐格里属物种进行了在琼脂糖下迁移能力的测试。致病性福氏耐格里菌株在37摄氏度时表现出快速移动。福氏耐格里的环境分离株比长期保存在无菌培养中的临床分离株移动得更快，使用在无菌培养中保存1个月或5个月的84 - 2205 - 7菌株证实了这一结果。非致病性格氏耐格里菌株在28摄氏度时能活跃迁移，但在37摄氏度时则不能；此外，即使在28摄氏度时，活跃的变形虫也只占整体的一小部分。耐温的非致病性物种洛万耐格里在37摄氏度时比福氏耐格里移动得更慢。相比之下，对小鼠具有致病性且耐温的澳大利亚耐格里，其迁移速度与福氏耐格里相当。自由生活变形虫的移动能力与其致病潜力之间似乎存在直接关联。
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