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用于生物医学应用的碳点在UM-UC-5和A549细胞中的安全性评估。

Safety Evaluation of Carbon Dots in UM-UC-5 and A549 Cells for Biomedical Applications.

作者信息

Magalhães Carla M, Ribeiro Eduarda, Fernandes Sónia, Esteves da Silva Joaquim, Vale Nuno, Pinto da Silva Luís

机构信息

Chemistry Research Unit (CIQUP), Institute of Molecular Sciences, Department of Geosciences, Environment, and Spatial Plannings, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007 Porto, Portugal.

PerMed Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.

出版信息

Cancers (Basel). 2024 Sep 29;16(19):3332. doi: 10.3390/cancers16193332.

DOI:10.3390/cancers16193332
PMID:39409951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11475197/
Abstract

BACKGROUNG

The rising complexity and associated side effects of cancer treatments highlight the need for safer and more effective therapeutic agents. Carbon-based nanomaterials such as CDs have been gaining prominence for their unique characteristics, opening avenues for diverse applications such as fluorescence imaging, drug and gene transport, controlled drug delivery, medical diagnosis, and biosensing. Despite promising advancements in research, it remains imperative to scrutinize the properties and potential cytotoxicity of newly developed CDs, ensuring their viability for these applications.

METHODS

We synthesized four N-doped CDs through a hydrothermal method. Cell viability assays were conducted on A549 and UM-UC-5 cancer cells at a range of concentrations and incubation times, both individually and with the chemotherapeutic agent 5-fluorouracil (5-FU).

RESULTS

The obtained results suggest that the newly developed CDs exhibit suitability for applications such as bioimaging, as no significant impact on cell viability was observed for CDs alone.

摘要

背景

癌症治疗日益复杂且伴有副作用，这凸显了对更安全、更有效治疗药物的需求。诸如碳点（CDs）之类的碳基纳米材料因其独特特性而备受关注，为荧光成像、药物和基因转运、可控药物递送、医学诊断及生物传感等多种应用开辟了道路。尽管研究取得了令人鼓舞的进展，但仍有必要仔细研究新开发的碳点的性质及其潜在细胞毒性，以确保它们在这些应用中的可行性。

方法

我们通过水热法合成了四种氮掺杂碳点。在一系列浓度和孵育时间下，分别对A549和UM - UC - 5癌细胞以及与化疗药物5 - 氟尿嘧啶（5 - FU）一起进行细胞活力测定。

结果

所得结果表明，新开发的碳点适用于生物成像等应用，因为单独使用碳点时未观察到对细胞活力有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/65a93bc44619/cancers-16-03332-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/df0d56c1d79f/cancers-16-03332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/e8e4cb2652cc/cancers-16-03332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/3c680bde0220/cancers-16-03332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/7058ee1f8ced/cancers-16-03332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/51bce326eec6/cancers-16-03332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/48165fa18be1/cancers-16-03332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/a38f3367a789/cancers-16-03332-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/ca48737460e0/cancers-16-03332-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/008c3e0f520e/cancers-16-03332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/0ea5627e7c85/cancers-16-03332-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/f32af7399962/cancers-16-03332-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/1579b77330ad/cancers-16-03332-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/65a93bc44619/cancers-16-03332-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/df0d56c1d79f/cancers-16-03332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/e8e4cb2652cc/cancers-16-03332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/3c680bde0220/cancers-16-03332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/7058ee1f8ced/cancers-16-03332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/51bce326eec6/cancers-16-03332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/48165fa18be1/cancers-16-03332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/a38f3367a789/cancers-16-03332-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/ca48737460e0/cancers-16-03332-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/008c3e0f520e/cancers-16-03332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/0ea5627e7c85/cancers-16-03332-g010a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/f32af7399962/cancers-16-03332-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/1579b77330ad/cancers-16-03332-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f6/11475197/65a93bc44619/cancers-16-03332-g013.jpg

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