Tian Zhibiao, Fu Yatian, Dang Zhiyong, Guo Tao, Li Wenjuan, Zhang Jing
College of Basic Medicine, Hebei University, Baoding 071000, China.
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
Nanomaterials (Basel). 2025 Mar 12;15(6):434. doi: 10.3390/nano15060434.
Microfluidic technology has gained widespread application in the field of biomedical research due to its exceptional sensitivity and high specificity. Particularly when combined with nanomaterials, the synergy between the two has significantly advanced fields such as precision medicine, drug delivery, disease detection, and treatment. This article aims to provide an overview of the latest research achievements of microfluidic nanomaterials in disease detection and treatment. It delves into the applications of microfluidic nanomaterials in detecting blood parameters, cardiovascular disease markers, neurological disease markers, and tumor markers. Special emphasis is placed on their roles in disease treatment, including models such as blood vessels, the blood-brain barrier, lung chips, and tumors. The development of microfluidic nanomaterials in emerging medical technologies, particularly in skin interactive devices and medical imaging, is also introduced. Additionally, the challenges and future prospects of microfluidic nanomaterials in current clinical applications are discussed. In summary, microfluidic nanomaterials play an indispensable role in disease detection and treatment. With the continuous advancement of technology, their applications in the medical field will become even more profound and extensive.
微流控技术因其卓越的灵敏度和高特异性,已在生物医学研究领域得到广泛应用。特别是当与纳米材料结合时,两者之间的协同作用显著推动了精准医学、药物递送、疾病检测和治疗等领域的发展。本文旨在概述微流控纳米材料在疾病检测和治疗方面的最新研究成果。它深入探讨了微流控纳米材料在检测血液参数、心血管疾病标志物、神经疾病标志物和肿瘤标志物方面的应用。特别强调了它们在疾病治疗中的作用,包括血管、血脑屏障、肺芯片和肿瘤等模型。还介绍了微流控纳米材料在新兴医疗技术中的发展,特别是在皮肤交互设备和医学成像方面。此外,还讨论了微流控纳米材料在当前临床应用中面临的挑战和未来前景。总之,微流控纳米材料在疾病检测和治疗中发挥着不可或缺的作用。随着技术的不断进步,它们在医学领域的应用将变得更加深入和广泛。