Shayan Arezoo, Refaei Mansoureh, Parsapour Hamideh, Masoumi Seyedeh Zahra, Ahmadinia Hassan, Moradkhani Shirin, Sattari Mahtab, Hamoun Minoo
Department of Midwifery and Reproductive Health, Mother and Child Care Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Mother and Child Health, Mother and Child Care Research Center, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.
Rev Recent Clin Trials. 2025;20(1):68-78. doi: 10.2174/0115748871317272240930092220.
Postpartum hemorrhage (PPH) is one of the three leading causes of maternal mortality. Herbal medicine is one of the well-known methods of treatment in the world.
This study was conducted to determine and compare the effect of dates, grape seed and dill seed extracts on the PPH rate in women in the fourth stage of labor.
Two hundred eligible multiparous women visiting the maternity ward in Hamadan for normal delivery participated in this double-blind parallel-group clinical trial. They were randomly divided into four 50-member groups of experiment (3 groups) and control (1 group). The data were collected using a researcher-made questionnaire. In the experimental groups, in addition to routine care and oxytocin administration, the mothers received a capsule containing 15 mg of dill seeds extract or 20 mg of grape seed extract or 5 g of dates extract immediately after the delivery, and then their hemorrhage rates were measured one and two hours after delivery. The control group received routine care, oxytocin, and placebo. Data were analyzed in SPSS 21.
The hemorrhage changes in the placebo group were much less than the intervention groups at 1 and 2 hours after delivery, and the four groups had a significant difference in terms of hemorrhage in both hours (p <0.001). The overall difference between the dates extract group and the placebo and grape seed groups was also statistically significant (p <0.05).
All three extracts of dates, grape seed and dill seeds, especially dates, can be effective in PPH reduction.
产后出血（PPH）是孕产妇死亡的三大主要原因之一。草药是世界上广为人知的治疗方法之一。
本研究旨在确定并比较枣、葡萄籽和莳萝籽提取物对分娩第四阶段妇女产后出血率的影响。
200名符合条件的经产妇到哈马丹产科病房进行正常分娩，参与了这项双盲平行组临床试验。她们被随机分为四个组，每组50人，其中实验组3组，对照组1组。数据通过研究者自制的问卷收集。在实验组中，除常规护理和使用催产素外，母亲们在分娩后立即服用一粒含有15毫克莳萝籽提取物或20毫克葡萄籽提取物或5克枣提取物的胶囊，然后在分娩后1小时和2小时测量她们的出血率。对照组接受常规护理、催产素和安慰剂。数据在SPSS 21中进行分析。
安慰剂组在分娩后1小时和2小时的出血变化远小于干预组，且四组在这两个小时的出血方面有显著差异（p<0.001）。枣提取物组与安慰剂组和葡萄籽组之间的总体差异也具有统计学意义（p<0.05）。
枣、葡萄籽和莳萝籽的所有三种提取物，尤其是枣，在降低产后出血方面可能有效。
