Ghalandari Sahar, Kariman Nourossadat, Sheikhan Zohre, Mojab Faraz, Mirzaei Moghadameh, Shahrahmani Hadis
1 Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
2 Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
J Altern Complement Med. 2017 Oct;23(10):794-799. doi: 10.1089/acm.2017.0095. Epub 2017 Jun 7.
Postpartum hemorrhage (PPH) is one of three main causes of maternal mortality and a life-threatening condition throughout the world. PPH can have irreversible complications for the mother even if it does not lead to death. This study was conducted to determine the effect of hydroalcoholic extract of Capsella bursa pastoris on early PPH.
The present study was a single-blinded, randomized, clinical trial.
The study was conducted in Afzalipour Hospital of Kerman in 2015.
The subjects included 100 women who had given vaginal birth and met the study inclusion criteria.
The participants were selected and randomly assigned into an intervention group (n = 50) and a placebo group (n = 50). Immediately after placental expulsion, the intervention group was given 10 sublingual drops of the hydroalcoholic extract of Capsella bursa pastoris plus an infusion of 20 U of oxytocin in 1 L of Ringer's solution, and the control group was given 10 sublingual drops of the placebo plus an infusion of 20 U of oxytocin in 1 L of Ringer's solution.
The amount of bleeding was assessed in both groups. Hemoglobin and hematocrit levels were measured in all the participants 6 h after childbirth. The statistical analysis of the data was performed in SPSS-17 using the following tests: independent t, paired t, repeated measures ANOVA, Friedman's, Wilcoxon, Mann-Whitney, Fisher's exact, and chi square. P-value <0.05 was considered statistically significant.
There were no significant differences between groups in baseline characteristics (p > 0.05). After the intervention, there was significant decrease in the amount of postpartum bleeding in both groups. However, the mean decrease in the amount of bleeding was significantly more in the Capsella bursa pastoris group (p < 0.001).
Compared with the mere administration of oxytocin, sublingual Capsella bursa drops appear to be effective in reducing PPH in this study. Further research regarding the efficacy and safety of various doses of Capsella bursa pastoris is required.
产后出血（PPH）是全球孕产妇死亡的三大主要原因之一，是一种危及生命的病症。即使PPH未导致产妇死亡，也可能给其带来不可逆的并发症。本研究旨在确定荠菜水醇提取物对早期PPH的影响。
本研究为单盲、随机临床试验。
该研究于2015年在克尔曼的阿夫扎利普尔医院开展。
研究对象包括100名经阴道分娩且符合研究纳入标准的女性。
将参与者选取并随机分为干预组（n = 50）和安慰剂组（n = 50）。胎盘娩出后立即给予干预组10滴荠菜水醇提取物舌下含服，加用20 U缩宫素溶于1 L林格氏液静脉滴注；对照组给予10滴安慰剂舌下含服，加用20 U缩宫素溶于1 L林格氏液静脉滴注。
评估两组的出血量。在产后6小时测量所有参与者的血红蛋白和血细胞比容水平。使用以下检验方法在SPSS - 17中对数据进行统计分析：独立样本t检验、配对t检验、重复测量方差分析、弗里德曼检验、威尔科克森检验、曼 - 惠特尼检验、费舍尔精确检验和卡方检验。P值<0.05被认为具有统计学意义。
两组的基线特征无显著差异（p>0.05）。干预后，两组的产后出血量均显著减少。然而，荠菜组的平均出血量减少幅度显著更大（p<0.001）。
在本研究中，与单纯使用缩宫素相比，舌下含服荠菜滴剂似乎能有效减少PPH。需要进一步研究不同剂量荠菜的疗效和安全性。
