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意外胆囊癌的管理实践

Practices in the Management of Incidental Gallbladder Cancer.

作者信息

Varshney Peeyush, Nagar Anand, Sarin Shashwat, Venkatatelikicherla Krishnavardhan, Tomar Maunil, Choubey R P, Sharma Ajay, Kapoor V K

机构信息

Department of Surgical Gastroenterology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Department of Hepato-Pancreato-Biliary Surgery, Mahatma Gandhi Medical College and Hospitals, Jaipur, Rajasthan, India.

出版信息

South Asian J Cancer. 2023 Aug 10;13(3):177-184. doi: 10.1055/s-0043-1764151. eCollection 2024 Jul.

DOI:10.1055/s-0043-1764151
PMID:39410985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11473137/
Abstract

Peeyush Varshney  Histopathology of gallbladder removed for stones may reveal incidental gallbladder cancer (iGBC). We conducted this online e-survey to document the knowledge and practices of management of iGBC among surgeons in India.  A 38-question online e-survey  Two-hundred thirty responses were recorded. Ninety-eight out of two-hundred (49%) responses were general surgeons. Two-hundred ten out of two-hundred twenty-one (95%) saw at least one iGBC per year, but only 74/225 (32%) correctly defined true iGBC. One-hundred seventy-eight out of two hundred twenty-two (80%) did computed tomography/magnetic resonance imaging for thick-walled gallbladder (GB) detected on ultrasound, while 25/222 (11%) did laparoscopic cholecystectomy and 14/222 (6%) did open cholecystectomy. For GB mass on laparoscopy, 16/222 (7%) responses went ahead with simple cholecystectomy. Seventy-four out of two-hundred twenty-five (32%) responses routinely used bag while extracting GB. One-hundred ninety-one out of two-hundred twenty-five (86%) mentioned about stone/bile spill, 121/220 (55%) mentioned about use of bag for extraction while 137/220 62% mentioned port used for extraction of GB in operation notes. One-hundred sixty-six out of two-hundred twenty-seven (73%) always cut open GB after cholecystectomy. On encountering a mass/lesion on cut open GB, 111/225 (49%) sent it for frozen section, 89/225 (40%) sent for routine histopathology while 10% (22/225) directly proceeded for extended cholecystectomy. Ten out of two-hundred twenty-seven (4.4%) did not consider it important to send GB for histopathology. T stage on histopathology is most important factor for deciding reoperation by 205/223 (91%).  There are lacunae in understanding and deficiencies in management of iGBC in India-a high GBC incidence country. The situation is likely to be worse in low GBC incidence areas. There is need for more awareness and knowledge for proper management of iGBC among surgeons.

摘要

佩尤什·瓦尔什尼 因结石而切除的胆囊的组织病理学检查可能会意外发现胆囊癌(iGBC)。我们开展了这项在线电子调查,以记录印度外科医生对iGBC的管理知识和实践情况。

  • 一项包含38个问题的在线电子调查

  • 共记录到230份回复。200份回复中有98份(49%)来自普通外科医生。221份回复中有210份(95%)每年至少见过1例iGBC,但只有225份回复中的74份(32%)正确定义了真正的iGBC。222份回复中有178份(80%)对超声检查发现的胆囊壁增厚进行了计算机断层扫描/磁共振成像检查,而222份回复中有25份(11%)进行了腹腔镜胆囊切除术,222份回复中有14份(6%)进行了开腹胆囊切除术。对于腹腔镜检查发现的胆囊肿物,222份回复中有16份(7%)直接进行了单纯胆囊切除术。225份回复中有74份(32%)在取出胆囊时常规使用袋子。225份回复中有191份(86%)提到了结石/胆汁溢出,220份回复中有121份(55%)提到使用袋子进行取出,220份回复中有137份(62%)在手术记录中提到了用于取出胆囊的端口。227份回复中有166份(73%)在胆囊切除术后总是切开胆囊。在切开胆囊时遇到肿物/病变,225份回复中有111份(49%)送去做冰冻切片,225份回复中有89份(40%)送去做常规组织病理学检查,而10%(22/225)直接进行扩大胆囊切除术。227份回复中有10份(4.4%)认为将胆囊送去做组织病理学检查不重要。组织病理学上的T分期是223份回复中205份(91%)决定再次手术的最重要因素。

在印度这个胆囊癌发病率较高的国家,对iGBC的理解存在不足,管理也有缺陷。在胆囊癌发病率较低的地区,情况可能更糟。外科医生需要更多的意识和知识来正确管理iGBC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/c51791d9c7e9/10-1055-s-0043-1764151-i2250902-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/b546f1c0f5d9/10-1055-s-0043-1764151-i2250902-authorphoto.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/b667e806e72e/10-1055-s-0043-1764151-i2250902-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/308dfedb4982/10-1055-s-0043-1764151-i2250902-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/c51791d9c7e9/10-1055-s-0043-1764151-i2250902-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/b546f1c0f5d9/10-1055-s-0043-1764151-i2250902-authorphoto.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/b667e806e72e/10-1055-s-0043-1764151-i2250902-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/308dfedb4982/10-1055-s-0043-1764151-i2250902-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd7/11473137/c51791d9c7e9/10-1055-s-0043-1764151-i2250902-3.jpg

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Cureus. 2021 Jul 4;13(7):e16156. doi: 10.7759/cureus.16156. eCollection 2021 Jul.
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Degree of biliary tract violation during treatment of gallbladder adenocarcinoma is independently associated with development of peritoneal carcinomatosis.在胆囊腺癌治疗过程中胆道侵犯的程度与腹膜癌病的发展独立相关。
J Surg Oncol. 2021 Sep;124(4):581-588. doi: 10.1002/jso.26569. Epub 2021 Jun 11.
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The role of laparoscopic surgery in the surgical management of gallbladder carcinoma: A systematic review and meta-analysis.
腹腔镜手术在胆囊癌外科治疗中的作用:系统评价和荟萃分析。
Asian J Surg. 2021 Dec;44(12):1493-1502. doi: 10.1016/j.asjsur.2021.03.015. Epub 2021 Apr 22.
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Ann Surg Oncol. 2021 Jun;28(6):2925-2927. doi: 10.1245/s10434-021-09761-x. Epub 2021 Mar 4.
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Incidental Gallbladder Cancer on Cholecystectomy: Strategy for Re-resection of Presumed Benign Diseases from a Retrospective Multicenter Study by the Yokohama Clinical Oncology Group.胆囊切除术后偶然发现的胆囊癌:来自横滨临床肿瘤学组的回顾性多中心研究中对疑似良性疾病的再次切除策略。
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