Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3880, South Africa.
School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Biomed Pharmacother. 2022 Sep;153:113439. doi: 10.1016/j.biopha.2022.113439. Epub 2022 Jul 21.
Diabetic neuropathy is a risk factor for developing complications such as autonomic cardiovascular disease, osteoarthropathy, foot ulcers, and infections, which may be the direct cause of death. Even worse, patients plagued by this condition display painful neuropathic symptoms that are usually severe and frequently lead to depression, anxiety, and sleep disarrays, eventually leading to a poor quality of life. There is a general interest in evaluating the therapeutic properties of topical capsaicin cream as an effective agent for pain relief in these patients. As such, the current review makes use of major search engines like PubMed and Google Scholar, to bring an updated analysis of clinical studies reporting on the therapeutic effects of capsaicin in patients with painful diabetic neuropathy. In fact, most of the summarized literature indicates that topical capsaicin (0.075 %) cream, when applied to the painful areas for approximately 8 weeks, can reduce pain, which may lead to clinical improvements in walking, working, and sleeping in patients with painful diabetic neuropathy. The current review also discusses essential information on capsaicin, including its source, bioavailability profile, as well as treatment doses and duration, to highlight its therapeutic potential.
糖尿病性神经病是发生并发症的一个风险因素，如自主心血管疾病、骨关节炎、足部溃疡和感染，这些并发症可能是直接导致死亡的原因。更糟糕的是，患有这种疾病的患者会出现疼痛性神经病变症状，通常这些症状很严重，并且经常导致抑郁、焦虑和睡眠紊乱，最终导致生活质量下降。人们普遍对评估局部辣椒素乳膏的治疗特性感兴趣，因为它是缓解这些患者疼痛的有效药物。因此，本综述利用 PubMed 和 Google Scholar 等主要搜索引擎，对报告辣椒素治疗痛性糖尿病性神经病患者的临床研究进行了更新分析。事实上，大部分总结文献表明，将 0.075%浓度的辣椒素乳膏涂在疼痛区域大约 8 周，可以减轻疼痛，这可能会导致痛性糖尿病性神经病患者在行走、工作和睡眠方面的临床改善。本综述还讨论了辣椒素的重要信息，包括其来源、生物利用度概况以及治疗剂量和持续时间，以突出其治疗潜力。
