Department of Mechanics and Mathematics, Ivan Franko Lviv State University, Lviv, Ukraine.
Immun Inflamm Dis. 2024 Oct;12(10):e70040. doi: 10.1002/iid3.70040.
HIV is a contagious disease with reportedly high transmissibility, being spread worldwide, with certain mortality, allegedly presenting a burden to public health worldwide. The main objective of this study was to determine excessive HIV death risks at any time within any region or country of interest.
Current study presents a novel multivariate public health system bio-risk assessment approach that is particularly applicable to environmental multi-regional, biological, and public health systems, being observed over a representative period of time, yielding reliable long-term HIV deathrate assessment. Hence, the development of a new bio-statistical approach, that is, population-based, multicenter, and medical survey-based. The expansion of extreme value statistics from the univariate to the bivariate situation meets with numerous challenges. Firstly, the univariate extreme value types theorem cannot be directly extended to the bivariate (2D) case, - not to mention challenges with system dimensionality higher than 2D.
Existing bio-statistical methods that process spatiotemporal clinical observations of multinational bio-processes often do not have the advantage of efficiently dealing with high regional dimensionalities and complex nonlinear inter-correlations between different national raw datasets. Hence, this study advocates the direct application of the novel bio-statistical Gaidai method to a raw unfiltered clinical data set.
This investigation described the successful application of a novel bio-risk assessment approach, yielding reliable long-term HIV mortality risk assessments.
The suggested risk assessment methodology may be utilized in various public bio and public health clinical applications based on available raw patient survey datasets.
艾滋病病毒是一种具有高传染性的传染病,据称在全球范围内传播,死亡率高,对全球公共卫生造成负担。本研究的主要目的是确定在任何感兴趣的地区或国家的任何时间内,艾滋病病毒死亡风险是否过高。
本研究提出了一种新的多变量公共卫生系统生物风险评估方法,特别适用于环境多区域、生物和公共卫生系统,在代表性时间段内进行观察,可得出可靠的长期艾滋病病毒死亡率评估。因此,开发了一种新的生物统计方法,即基于人群、多中心和医疗调查的方法。将单变量极值统计从单变量扩展到双变量(二维)情况会遇到许多挑战。首先,单变量极值类型定理不能直接扩展到双变量(二维)情况,更不用说系统维度高于二维的挑战了。
现有的生物统计方法处理跨国生物过程的时空临床观察,通常没有优势来有效地处理高区域维度和不同国家原始数据集之间复杂的非线性相互关联。因此,本研究主张直接将新的生物统计 Gaidai 方法应用于原始未过滤的临床数据集。
本研究成功应用了一种新的生物风险评估方法,得出了可靠的长期艾滋病病毒死亡率风险评估。
所提出的风险评估方法可应用于基于现有原始患者调查数据集的各种公共生物和公共卫生临床应用。