Mei Lihua, Wang Jiaxin, Hao Yanling, Zeng Xiangfang, Yang Ying, Wu Zhenlong, Ji Yun
State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China.
Crit Rev Food Sci Nutr. 2024 Oct 16:1-18. doi: 10.1080/10408398.2024.2416481.
() has gained recognition as a pioneering probiotic, exhibiting considerable potential to enhance immune conditions across both humans and animals. The health benefits of are attributed to its various components, including outer membrane proteins (PilQ and Amuc_1100), secreted proteins (P9 and AmTARS), extracellular vesicles, and metabolites such as SCFAs, ornithine lipids, -aminobutyric acid, cobalamin, and inosine. The dynamic control of the mucus layer by plays a crucial role in regulating intestinal mucosal immunity. Furthermore, modulates immune function by interacting with macrophages, dendritic cells, T lymphocytes, and Paneth cells. Increasing the abundance of in the gut through nutritional strategies represents a safe and effective means to augment immune function. Various polyphenols, oligosaccharides, and polysaccharides have been shown to elevate the levels of this bacterium, thereby contributing to favorable immunoregulatory outcomes. This paper delves into the latest research advancements related to the probiotic mechanisms of and provides an overview of the current understanding of how its abundance responds to nutrients. These insights offer a theoretical foundation for the utilization of in immunoregulation.
（）已被公认为一种开创性的益生菌，在改善人类和动物的免疫状况方面具有巨大潜力。其健康益处归因于其各种成分，包括外膜蛋白（PilQ和Amuc_1100）、分泌蛋白（P9和AmTARS）、细胞外囊泡以及代谢产物，如短链脂肪酸、鸟氨酸脂质、γ-氨基丁酸、钴胺素和肌苷。它对黏液层的动态控制在调节肠道黏膜免疫中起着关键作用。此外，它通过与巨噬细胞、树突状细胞、T淋巴细胞和潘氏细胞相互作用来调节免疫功能。通过营养策略增加肠道中该菌的丰度是增强免疫功能的一种安全有效的手段。各种多酚、寡糖和多糖已被证明可提高这种细菌的水平，从而有助于产生良好的免疫调节效果。本文深入探讨了与该益生菌机制相关的最新研究进展，并概述了目前对其丰度如何响应营养物质的理解。这些见解为其在免疫调节中的应用提供了理论基础。
