Hole P, Andersen P K, Stokke D B, Rasmussen N J, Juhl B, Jørgensen S
Acta Anaesthesiol Scand. 1979 Jun;23(3):217-24. doi: 10.1111/j.1399-6576.1979.tb01443.x.
In 660 supine, intubated and anaesthetized, healthy patients scheduled for various elective surgical procedures, the distribution of arterial carbon dioxide tension (PaCO2) was investigated during manual non-monitored ventilation. The study comprised six equal groups: group 1: ventilation with a circle circuit absorber system; group 2: ventilation with the Hafnia A circuit using a total fresh gas flow (FGF) of 100 ml . kg-1 . min-1; groups 3-6: ventilation with a Hafnia D circuit with fresh gas flows of 100, 80, 70 and 60 ml . kg-1 . min-1, respectively. The mean PaCO2's of the first three groups were situated in the lower range of normocapnia (the observations in the first group having the greatest total range), whereas the rebreathing (Hafnia A and D) circuits resulted in a clustering of observed data. Employing the rebreathing circuits, protection against hypocapnia can be achieved by lowering the fresh gas flow. The most satisfying result was obtained with the Hafnia D circuit with a fresh gas flow of 70 ml . kg-1 . min-1 resulting in normocapnia with a modest and limited spread towards hypo- and hypercapnia. FGF in excess of this level must be considered as wasted. The study indicates that corrections of fresh gas flows for age are superfluous. Use of relaxants and type of surgery had no influence on the observations.
在660例仰卧、插管且麻醉的健康患者中,这些患者计划接受各种择期外科手术,在手动非监测通气期间研究了动脉血二氧化碳分压(PaCO2)的分布情况。该研究包括六个相等的组:第1组:使用环形回路吸收器系统通气;第2组:使用哈夫尼亚A回路通气,总新鲜气体流量(FGF)为100 ml·kg-1·min-1;第3 - 6组:使用哈夫尼亚D回路通气,新鲜气体流量分别为100、80、70和60 ml·kg-1·min-1。前三组的平均PaCO2处于正常碳酸血症的较低范围(第一组的观察值总范围最大),而重复呼吸(哈夫尼亚A和D)回路导致观察数据聚集。采用重复呼吸回路时,可通过降低新鲜气体流量来防止低碳酸血症。使用新鲜气体流量为70 ml·kg-1·min-1的哈夫尼亚D回路获得了最满意的结果,该回路可实现正常碳酸血症,向低碳酸血症和高碳酸血症的偏差适度且有限。超过该水平的FGF必须视为浪费。该研究表明,针对年龄校正新鲜气体流量是多余的。使用松弛剂和手术类型对观察结果没有影响。