Al-Ammari Maged, Hsu Danny, Bryant Adam
Department of Haematology Liverpool Hospital Liverpool Australia.
School of Clinical Medicine University of New South Wales Sydney Australia.
EJHaem. 2024 Jul 4;5(5):1057-1062. doi: 10.1002/jha2.975. eCollection 2024 Oct.
Hemophagocytic lymphohistiocytosis (HLH) is an immune response syndrome characterized by excessive inflammation and tissue destruction. A limited number of cases involving HLH patients with concomitant multiple myeloma (MM), leading to significant mortality, have been documented, underscoring the importance of timely diagnosis. We present the case of a 78-year-old previously healthy male admitted to our hospital with a newly diagnosed MM. Subsequently, he was diagnosed with HLH and received treatment with anakinra, intravenous immunoglobulin, and dexamethasone. This case report highlights the unique aspect of being the first documented instance of myeloma-associated HLH treated with anakinra.
噬血细胞性淋巴组织细胞增生症（HLH）是一种以过度炎症反应和组织破坏为特征的免疫反应综合征。有记录显示，少数HLH患者合并多发性骨髓瘤（MM），导致了显著的死亡率，这凸显了及时诊断的重要性。我们报告一例78岁既往健康男性，因新诊断的MM入住我院。随后，他被诊断为HLH，并接受了阿那白滞素、静脉注射免疫球蛋白和地塞米松治疗。本病例报告突出了其独特之处，即这是首例记录在案的接受阿那白滞素治疗的骨髓瘤相关HLH病例。
