K Karunakar Karthik, Cheriyan Binoy Varghese, R Krithikeshvaran, M Gnanisha, B Abinavi
Department of Pharmacy Practice, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, India.
Department of Pharmaceutical Chemistry, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, 602105, TN, India.
Biotechnol Notes. 2024 Jun 1;5:64-79. doi: 10.1016/j.biotno.2024.05.002. eCollection 2024.
Nanotechnology has the advantages of enhanced bioactivity, reduced toxicity, target specificity, and sustained release and NPs can penetrate cell membranes. The small size of silver nanoparticles, AgNPs, large surface area, and unique physicochemical properties contribute to cell lysis and increased permeability of cell membranes used in the field of biomedicine. Functional precursors integrate with phytochemicals to create distinctive therapeutic properties and the stability of the nanoparticles can be enhanced by Surface coatings and encapsulation methods, The current study explores the various synthesis methods and characterization techniques of silver nanoparticles (AgNPs) and highlights their intrinsic activity in therapeutic applications, Anti-cancer activity noted at a concentration range of 5-50 μg/ml and angiogenesis is mitigated at a dosage range of 10-50 μg/ml, Diabetes is controlled within the same concentration. Wound healing is improved at concentrations of 10-50 μg/ml and with a typical range of 10-08 μg/ml for bacteria with antimicrobial capabilities. Advancement of silver nanoparticles with a focus on the future use of AgNPs-coated wound dressings and medical devices to decrease the risk of infection. Chemotherapeutic drugs can be administered by AgNPs, which reduces adverse effects and an improvement in treatment outcomes. AgNPs have been found to improve cell proliferation and differentiation, making them beneficial for tissue engineering and regenerative medicine. Our study highlights emerging patterns and developments in the field of medicine, inferring potential future paths.
纳米技术具有增强的生物活性、降低的毒性、靶向特异性和缓释性等优点，并且纳米粒子可以穿透细胞膜。银纳米粒子（AgNPs）尺寸小、比表面积大以及具有独特的物理化学性质，这些特性有助于细胞裂解并增加生物医学领域中细胞膜的通透性。功能性前体与植物化学物质结合可产生独特的治疗特性，并且通过表面涂层和封装方法可以提高纳米粒子的稳定性。当前的研究探索了银纳米粒子（AgNPs）的各种合成方法和表征技术，并突出了它们在治疗应用中的内在活性。在5-50μg/ml的浓度范围内观察到抗癌活性，在10-50μg/ml的剂量范围内可减轻血管生成。在相同浓度下可控制糖尿病。在10-50μg/ml的浓度下伤口愈合得到改善，对于具有抗菌能力的细菌，典型范围为10-08μg/ml。重点关注未来使用涂有AgNPs的伤口敷料和医疗设备以降低感染风险，推动银纳米粒子的发展。化疗药物可以通过AgNPs给药，这可减少副作用并改善治疗效果。已发现AgNPs可改善细胞增殖和分化，使其有利于组织工程和再生医学。我们的研究突出了医学领域中新兴的模式和发展，推断了潜在的未来路径。
