Liu Meishan, Yan Ran, Lu Shaoteng, Zhang Ping, Xu Sheng
National Key Laboratory of Immunity and Inflammation and Institute of Immunology, Navy Medical University/Second Military Medical University Shanghai 200433, China.
Department of Neurology, Naval Medical Center of PLA, Naval Medical University Shanghai 200052, China.
Am J Cancer Res. 2024 Sep 15;14(9):4197-4217. doi: 10.62347/WVVG5364. eCollection 2024.
Depression is a common co-morbidity among cancer cases, which has a detrimental influence on cancer treatment and prognosis. Recent advancements in the neurobiology of depression and cancer pathophysiology have revealed several shared biobehavioral mechanisms and introduced new therapeutic strategies. In this review, we summarize the biological mechanisms driving cancer-related depression, including psychosocial factors, immuno-inflammatory processes, chronic stress, dysbiosis of gut microbiota, and medically-induced factors. Interventions used for cancer-related depression may include psychosocial therapies, pharmacological therapies, immunotherapies, psychobiological medications, and dietary strategies. This review could inspire the elucidation of possible co-occurring mechanisms and complex interactions between cancer and depression, provide an opportunity to propose faster and more effective therapies for cancer-related depression, and well as new strategies for cancer in the future.
抑郁症是癌症患者中常见的共病，对癌症治疗和预后有不利影响。抑郁症神经生物学和癌症病理生理学的最新进展揭示了几种共同的生物行为机制，并引入了新的治疗策略。在本综述中，我们总结了导致癌症相关抑郁症的生物学机制，包括心理社会因素、免疫炎症过程、慢性应激、肠道微生物群失调和医源性因素。用于癌症相关抑郁症的干预措施可能包括心理社会治疗、药物治疗、免疫治疗、心理生物药物和饮食策略。本综述可能会激发对癌症与抑郁症之间可能的共同发生机制和复杂相互作用的阐明，为提出更快、更有效的癌症相关抑郁症治疗方法提供机会，以及为未来的癌症治疗提供新策略。
