Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis The Ohio State University College of Medicine 700 Children's Drive, WA5021 Columbus, OH 43205, USA.
Curr Opin Struct Biol. 2024 Dec;89:102943. doi: 10.1016/j.sbi.2024.102943. Epub 2024 Oct 16.
Intracellular DNA primarily serves as the cellular genetic material both in eukaryotes and prokaryotes. This function is often regulated by alterations in the DNA structure to accommodate transcription, recombination, and DNA replication. Extracellularly, both eukaryotic and prokaryotic cells take advantage of DNA plenty in addition to a permissive environment and create novel structures to fulfill multiple new roles. As often occurs intracellularly, extracellular DNA requires proteins to facilitate and stabilize these important structures. Here I review, both host and eubacterial nucleoprotein structures, their composition, their functions, and how these distinct structures can interact. Even at this early stage of study, it is clear that extracellular chromatin plays important biological roles in the survival of both prokaryotic and eukaryotic organisms.
细胞内 DNA 主要作为真核生物和原核生物的细胞遗传物质。这种功能通常通过改变 DNA 结构来调节，以适应转录、重组和 DNA 复制。在细胞外，真核生物和原核生物细胞除了利用有利的环境外，还利用大量的 DNA 来创造新的结构，以满足多种新的功能。正如细胞内经常发生的那样，细胞外 DNA 需要蛋白质来促进和稳定这些重要的结构。在这里，我回顾了宿主和细菌核蛋白结构、它们的组成、它们的功能，以及这些不同结构如何相互作用。即使在研究的早期阶段，也很明显，细胞外染色质在原核生物和真核生物的生存中发挥着重要的生物学作用。
