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可降解生物医用聚合物在疾病的预防、诊断和治疗中的最新进展。

Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases.

机构信息

State Key Laboratory of Physical Chemistry of Solid Surfaces, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.

Shenzhen Research Institute of Xiamen University, Shenzhen 518000, China.

出版信息

Biomacromolecules. 2024 Nov 11;25(11):7015-7057. doi: 10.1021/acs.biomac.4c01193. Epub 2024 Oct 17.

Abstract

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing a wide range of applications. Their unique advantages, such as rich source, good biocompatibility, and excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, and tissue engineering. However, conventional biomedical polymers suffer from poor degradation , increasing the risks of bioaccumulation and potential toxicity. To address these issues, degradable biomedical polymers can serve as an alternative strategy in biomedicine. Degradable biomedical polymers can efficiently relieve bioaccumulation and effectively reduce patient burden in disease management. This review comprehensively introduces the classification and properties of biomedical polymers and the recent research progress of degradable biomedical polymers in various diseases. Through an in-depth analysis of their classification, properties, and applications, we aim to provide strong guidance for promoting basic research and clinical translation of degradable biomedical polymers.

摘要

生物医学聚合物在预防、诊断和治疗疾病方面发挥着关键作用,具有广泛的应用。它们独特的优势,如丰富的来源、良好的生物相容性和优异的可修饰性,使它们成为药物输送、生物医学成像和组织工程的理想生物材料。然而,传统的生物医学聚合物降解性差,增加了生物累积和潜在毒性的风险。为了解决这些问题,可降解生物医学聚合物可以作为生物医学中的一种替代策略。可降解生物医学聚合物可以有效地缓解生物累积,并在疾病管理中有效减轻患者负担。本综述全面介绍了生物医学聚合物的分类和性质,以及可降解生物医学聚合物在各种疾病中的最新研究进展。通过对其分类、性能和应用的深入分析,旨在为促进可降解生物医学聚合物的基础研究和临床转化提供有力指导。

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