Renaud S, Godsey F, Dumont E, Thevenon C, Ortchanian E, Martin J L
Am J Clin Nutr. 1986 Jan;43(1):136-50. doi: 10.1093/ajcn/43.1.136.
Platelet function and composition, lipemia, and dietary habits were evaluated yearly in 98 male farmers from Moselle (East of France) before and after decreasing, in half of them, dietary saturated fats from 16.2% to 9.9% of calories (P/S from 0.32 to 0.97). One year after these dietary changes, cholesterol and triglycerides decreased by approximately 10%, platelet aggregation to thrombin by 81%, and their clotting activity by 30%. However, ADP aggregation was enhanced by 54%. At 2 yr the P/S was decreased to 0.7 and diet also modified in controls, with 18:2 being increased mostly in one group (P/S = 0.81) and 18:3 in another (P/S = 0.59). In both groups, the main platelet function tests were significantly depressed 1 yr later. Considering the whole study, the intake of saturated fat was mostly correlated (group and individual) with platelet aggregation to thrombin, platelet clotting activity, and 20:3 (n-9) in plasma and platelet lipids.
对来自法国东部摩泽尔地区的98名男性农民的血小板功能和成分、血脂以及饮食习惯进行了年度评估，其中一半人的饮食中饱和脂肪摄入量从热量的16.2%降至9.9%（多不饱和脂肪酸与饱和脂肪酸的比例从0.32升至0.97）。这些饮食改变一年后，胆固醇和甘油三酯下降了约10%，血小板对凝血酶的聚集能力下降了81%，凝血活性下降了30%。然而，对二磷酸腺苷的聚集能力增强了54%。两年后，多不饱和脂肪酸与饱和脂肪酸的比例降至0.7，对照组的饮食也发生了改变，一组主要增加了亚油酸（多不饱和脂肪酸与饱和脂肪酸的比例 = 0.81），另一组主要增加了亚麻酸（多不饱和脂肪酸与饱和脂肪酸的比例 = 0.59）。两组在一年后主要血小板功能测试均显著降低。综合整个研究来看，饱和脂肪的摄入量（无论是组间还是个体）与血小板对凝血酶的聚集能力、血小板凝血活性以及血浆和血小板脂质中的二十碳三烯酸（n-9）大多存在相关性。
