Renaud S, Morazain R, Godsey F, Dumont E, Thevenon C, Martin J L, Mendy F
Atherosclerosis. 1986 Apr;60(1):37-48. doi: 10.1016/0021-9150(86)90085-7.
In 260 male farmers (40-45 years) divided into 9 groups from different areas in France and Britain, coagulation, platelet aggregation, lipemia, fatty acids from plasma lipids and platelet phospholipids were determined in relation to the food intake evaluated by recall, weighing and chemical analysis of the diet. The clotting activity of platelets and their response to thrombin aggregation was significantly correlated on an individual basis with the intake of saturated fatty acids both in subsamples as well as in the whole study. Serum cholesterol was also significantly correlated with saturated fats but only on a group basis or on the totality of the study. Calcium, linolenic acid and alcohol in the diet were inversely related to certain platelet functions. Linoleic acid was inversely related to serum cholesterol and triglycerides. Dietary saturated fats were associated, with an increase in the platelet phospholipids not in saturated fatty acids but in 20:3 (n-9), known to promote platelet aggregation to thrombin, with a decrease in platelet cholesterol, also apparently regulating platelet functions. The present studies indicate that dietary saturated fats, calcium (hard water) and alcohol, influence platelet behaviour in a way strictly parallel to their known effect on coronary heart disease.
在来自法国和英国不同地区的260名年龄在40至45岁之间的男性农民中，他们被分成9组，通过饮食回忆、称重及化学分析对食物摄入量进行评估，并测定了凝血、血小板聚集、血脂、血浆脂质中的脂肪酸以及血小板磷脂。在各个子样本以及整个研究中，血小板的凝血活性及其对凝血酶聚集的反应与饱和脂肪酸的摄入量在个体层面上显著相关。血清胆固醇也与饱和脂肪显著相关，但仅在组间层面或整个研究层面上如此。饮食中的钙、亚麻酸和酒精与某些血小板功能呈负相关。亚油酸与血清胆固醇和甘油三酯呈负相关。饮食中的饱和脂肪与血小板磷脂的增加有关，增加的不是饱和脂肪酸，而是已知可促进血小板对凝血酶聚集的20:3（n-9），同时血小板胆固醇减少，这显然也在调节血小板功能。目前的研究表明，饮食中的饱和脂肪、钙（硬水）和酒精对血小板行为的影响方式与它们对冠心病的已知影响严格平行。
