McGregor L, Morazain R, Renaud S
Atherosclerosis. 1981 Jan-Feb;38(1-2):129-36. doi: 10.1016/0021-9150(81)90110-6.
Spontaneously hypertensive rats (Okamoto-Wistar) as compared to their normotensive controls (Kyoto-Wistar) presented a markedly higher platelet activity both in coagulation (as evaluated by the recalcification plasma clotting time of platelet-rich plasma) and aggregation, as triggered by thrombin. By comparing animals fed saturated or polyunsaturated fat, it could be observed that the saturated fat diet induced similar results on platelet functions to these observed in hypertension. In addition, the saturated fat diet further increased the platelet response of the hypertensive animals. By contrast, the polyunsaturated fat, could neither reduce the hypertension nor completely abolish the platelet reactivity associated with the hypertension. The most significant change induced by the saturated fat diet in the fatty acid composition of the platelet phospholipids was an increase in 20:3 omega 9, further enhanced in the hypertensive animals. In the polyunsaturated diet-fed rats, it was mostly 20:4 which was more elevated in the platelet phospholipids of the hypertensive. As a result, it was the sum of 20:3 omega 9 + 20:4 in the platelet phospholipids, which appeared to be the most significantly related, in the 4 groups of animals, to the response of platelets to thrombin induced aggregation.
与正常血压对照大鼠（京都-威斯塔大鼠）相比，自发性高血压大鼠（冈本-威斯塔大鼠）在凝血（通过富含血小板血浆的复钙血浆凝血时间评估）和聚集方面均表现出明显更高的血小板活性，聚集由凝血酶触发。通过比较喂食饱和脂肪或多不饱和脂肪的动物，可以观察到饱和脂肪饮食对血小板功能产生的结果与高血压中观察到的相似。此外，饱和脂肪饮食进一步增加了高血压动物的血小板反应。相比之下，多不饱和脂肪既不能降低高血压，也不能完全消除与高血压相关的血小板反应性。饱和脂肪饮食引起的血小板磷脂脂肪酸组成的最显著变化是20:3 ω9增加，在高血压动物中进一步增强。在喂食多不饱和饮食的大鼠中，血小板磷脂中升高较多的主要是20:4。结果，在4组动物中，血小板磷脂中20:3 ω9 + 20:4的总和似乎与血小板对凝血酶诱导聚集的反应最显著相关。
