Departamento de Clínica Médica Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Departamento de Ginecologia Faculdade de Medicina Universidade Federal de Minas Gerais Belo HorizonteMG Brasil Departamento de Ginecologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Arch Endocrinol Metab. 2024 Jun 24;68:e230271. doi: 10.20945/2359-4292-2023-0271. eCollection 2024.
The aim of this study was to evaluate the efficacy of a self-assessment questionnaire for hirsutism using the latest cutoff values recommended by the Endocrine Society (ES) for Latin-American women and by the European Society for Human Reproduction and Embryology (ESHRE).
Female premenopausal outpatients (n = 188) completed a self-assessment questionnaire, scoring hair presence across the nine areas evaluated by the modified Ferriman-Gallwey (mFG) scale. The results were compared with clinician-assessed scores rated independently by two trained physicians. Scores in the Hirsuta questionnaire, derived from self-assessment of five areas of the mFG scale, were also evaluated.
The ethnic composition of the sample was as follows: 23.1% white, 25.8% black, 48.9% mixed, and 2.1% other backgrounds (Indigenous, Asian). The participants had age and BMI of (mean ± standard deviation) 33.7 ± 9.9 years and 29.8 ± 7.21 kg/m, respectively. The most common areas of excessive hair growth were the chin, upper and lower abdomen, and thighs. Relative to clinician-assessed mFG scores, self-assessed mFG scores had an accuracy of 80% using ES criteria for hirsutism diagnosis, with a sensitivity of 95.45%, specificity of 56.25%, positive predictive value of 30.10%, and negative predictive value of 98.40%. Self-assessed mFG had lower accuracy (71%) for diagnosing hirsutism when the ESHRE criteria were applied.
Self-assessed mFG had low specificity, limiting its application. The results of this study do not support the use of the self-assessed mFG or Hirsuta scores for diagnosing hirsutism in a clinical setting, although both scoring systems may be useful for screening hirsutism in epidemiological studies.
本研究旨在评估采用内分泌学会(ES)推荐的最新拉丁裔女性 cutoff 值和欧洲人类生殖与胚胎学会(ESHRE)推荐的 cutoff 值的多毛症自我评估问卷的疗效。
188 例绝经前女性门诊患者完成了改良 Ferriman-Gallwey(mFG)量表评估的 9 个区域毛发存在情况的自我评估问卷。结果与由两名训练有素的医生独立评估的临床医生评估评分进行比较。还评估了源自 mFG 量表 5 个区域自我评估的 Hirsuta 问卷评分。
样本的种族构成如下:23.1%为白人,25.8%为黑人,48.9%为混血,2.1%为其他背景(土著、亚洲)。参与者的年龄和 BMI 分别为(平均值±标准差)33.7±9.9 岁和 29.8±7.21kg/m2。最常见的多毛区域是下巴、上下腹部和大腿。与临床医生评估的 mFG 评分相比,采用 ES 多毛症诊断标准,自我评估的 mFG 评分具有 80%的准确性,其灵敏度为 95.45%,特异性为 56.25%,阳性预测值为 30.10%,阴性预测值为 98.40%。当应用 ESHRE 标准时,自我评估的 mFG 对诊断多毛症的准确性较低(71%)。
自我评估的 mFG 特异性较低,限制了其应用。本研究结果不支持在临床环境中使用自我评估的 mFG 或 Hirsuta 评分来诊断多毛症,尽管这两种评分系统在流行病学研究中筛查多毛症可能有用。