Huang Ruihan, Liu Yongsheng
School of Public Health, Qilu Medical University, Zibo, Shandong, China.
School of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Front Psychiatry. 2024 Oct 3;15:1463848. doi: 10.3389/fpsyt.2024.1463848. eCollection 2024.
Currently, depression-induced suicide has emerged as the primary contributor to the worldwide burden of disability. However, the prevailing drug treatment not only suffers from delayed effectiveness and limited efficacy, but also there are withdrawal symptoms and rebound phenomenon. Consequently, there is an imperative to investigate safer and more efficient treatments to ameliorate the clinical manifestations of depression. At present, there is increased evidence that probiotics can improve the symptoms of depression, but the existing studies use many and mixed types of probiotics, and it is impossible to determine the specific efficacy of bifidobacteria in the treatment of depression. This review will systematically review the effects of bifidobacteria on the treatment effect of depression, Meta-analysis showed that Bifidobacterium-related preparations effectively improved depressive symptoms in patients with depression. This study represents the initial meta-analysis conducted on the use of bifidobacteria-related agents for treating depression. The objective was to determine the effect of bifidobacteria-related preparations on improving depressive symptoms. We found that Bifidobacterium and its related agents can effectively reduce depression scale scores in patients with depression, suggesting the need for further research into this potential strategy for the prevention and treatment of depression.
目前，抑郁症诱发的自杀已成为全球残疾负担的主要因素。然而，现有的药物治疗不仅起效延迟、疗效有限，还存在戒断症状和反跳现象。因此，迫切需要研究更安全、更有效的治疗方法来改善抑郁症的临床表现。目前，越来越多的证据表明益生菌可以改善抑郁症症状，但现有研究使用的益生菌种类繁多且混杂，无法确定双歧杆菌在治疗抑郁症中的具体疗效。本综述将系统评价双歧杆菌对抑郁症治疗效果的影响，荟萃分析表明，双歧杆菌相关制剂可有效改善抑郁症患者的抑郁症状。本研究是对使用双歧杆菌相关药物治疗抑郁症进行的首次荟萃分析。目的是确定双歧杆菌相关制剂对改善抑郁症状的效果。我们发现双歧杆菌及其相关制剂可有效降低抑郁症患者的抑郁量表评分，这表明有必要对这种预防和治疗抑郁症的潜在策略进行进一步研究。
