Grupo de Investigación en Salud Integral (GISI), Departamento Facultad de Salud, Universidad Santiago de Cali, Cali 760035, Colombia.
Área Servicio de Alimentación, Área Nutrición Clínica Hospitalización UCI Urgencias Y Equipo de Soporte nutricional, Clínica Nuestra, Cali 760041, Colombia.
Nutrients. 2024 Apr 30;16(9):1352. doi: 10.3390/nu16091352.
In this study, a systematic review of randomized clinical trials conducted from January 2000 to December 2023 was performed to examine the efficacy of psychobiotics-probiotics beneficial to mental health via the gut-brain axis-in adults with psychiatric and cognitive disorders. Out of the 51 studies involving 3353 patients where half received psychobiotics, there was a notably high measurement of effectiveness specifically in the treatment of depression symptoms. Most participants were older and female, with treatments commonly utilizing strains of Lactobacillus and Bifidobacteria over periods ranging from 4 to 24 weeks. Although there was a general agreement on the effectiveness of psychobiotics, the variability in treatment approaches and clinical presentations limits the comparability and generalization of the findings. This underscores the need for more personalized treatment optimization and a deeper investigation into the mechanisms through which psychobiotics act. The research corroborates the therapeutic potential of psychobiotics and represents progress in the management of psychiatric and cognitive disorders.
本研究对 2000 年 1 月至 2023 年 12 月期间进行的随机临床试验进行了系统回顾，以评估通过肠-脑轴对精神和认知障碍的成年人有益的心理益生菌(probiotics beneficial to mental health via the gut-brain axis)在治疗精神和认知障碍方面的疗效。在涉及 3353 名患者的 51 项研究中，有一半接受了心理益生菌治疗，其中特别在治疗抑郁症状方面的效果显著。大多数参与者年龄较大且为女性，治疗方法通常使用 Lactobacillus 和 Bifidobacteria 菌株，持续时间从 4 周到 24 周不等。尽管普遍认为心理益生菌有效，但治疗方法和临床表现的差异限制了研究结果的可比性和普遍性。这凸显了需要对个体化治疗进行优化，并深入研究心理益生菌的作用机制。该研究证实了心理益生菌的治疗潜力，代表着在精神和认知障碍管理方面取得了进展。
