Thor Danielle C, Ha Joann Y, Galiboglu Yasemin, Wong Kristine, Hou Cindy
Internal Medicine, Jefferson Health New Jersey, Stratford, USA.
Internal Medicine, Rowan-Virtua School of Osteopathic Medicine, Stratford, USA.
Cureus. 2024 Sep 17;16(9):e69585. doi: 10.7759/cureus.69585. eCollection 2024 Sep.
The advent of immunomodulatory therapies and their ever-expanding number of treatment indications necessitates the understanding of their associated complications. Neutropenic fever serves as an example of these complications often encountered in clinical practice. Although neutropenic fever can result from virtually any pathogen, episodes of the syndrome secondary to tick-borne illness remain relatively undocumented in the scientific literature. In the case presented, a 77-year-old female with a pertinent past medical history of smoldering IgG multiple myeloma on active immunosuppressive therapy presented with a first-time episode of neutropenic fever likely secondary to tick-borne illness. Through this report, attention is drawn to an additional source pathogen for neutropenic fever and its management, thus expanding upon clinician understanding of this all-too-common complication of immunosuppression.
免疫调节疗法的出现及其不断扩大的治疗适应症数量,使得有必要了解其相关并发症。中性粒细胞减少性发热就是临床实践中经常遇到的这类并发症的一个例子。虽然几乎任何病原体都可能导致中性粒细胞减少性发热,但蜱传疾病继发的该综合征病例在科学文献中仍然记载相对较少。在本文所述病例中,一名77岁女性,有意义的既往病史为无症状IgG型多发性骨髓瘤,正在接受积极的免疫抑制治疗,首次出现中性粒细胞减少性发热,可能继发于蜱传疾病。通过本报告,引起了对中性粒细胞减少性发热的另一种病原体来源及其管理的关注,从而扩展了临床医生对这种免疫抑制常见并发症的认识。