Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Department of Epidemiology, School of Public Health, Iran University of Medical Science, Tehran, Iran.
Front Endocrinol (Lausanne). 2024 Oct 3;15:1334496. doi: 10.3389/fendo.2024.1334496. eCollection 2024.
We conducted a systematic review and meta-analysis on dairy consumption and its association with anthropometric measurements, blood glucose status, insulin levels, and testosterone levels in women with Polycystic Ovary Syndrome.
This study conducted a comprehensive literature search using electronic databases like MEDLINE, Scopus, PubMed, Web of Science, and Google Scholar to identify observational and interventional studies investigating the relationship between dairy product consumption and Polycystic Ovary Syndrome. A meta-analysis was performed on clinical trial studies that examined the effect of a low starch/low dairy diet in Polycystic Ovary Syndrome subjects. Statistical analyses were performed using Stata version 16.0 (Stata Corporation, College Station, Texas, USA), and statistical significance was defined as p-value < 0.05.
Of the 1,313 citations reviewed, our systematic review identified 11 studies that met the inclusion criteria, comprising six case-control studies, four clinical trials, and one cross-sectional study. The case-control studies found limited evidence of an association between dairy consumption and Polycystic Ovary Syndrome. The result of the clinical trial studies in meta-analysis showed that reducing dairy intake along with reducing starch intake led to statistically significant improvements in anthropometric and metabolic measures including mean weight (Standardized mean difference: -8.43 (95% CI: -9.01, -7.86)), Body mass index (-3.14 (95% CI: -3.35, -2.92), waist circumference (-6.63 (95% CI: -10.70, -2.57)) and Waist-to-Height Ratio (-0.04 (95% CI: -0.07, -0.01), insulin fasting (-18.23 (95% CI: -22.11, -14.36)), insulin 120 minutes (-94.05 (95% CI: -157.67, -30.42)), HbA1c (-0.27 (95% CI: -0.37, -0.17)), Ferryman-Gallwey score (-2.07 (95% CI: -2.98, -1.16)) and total testosterone (-9.97 (95% CI: -14.75, -5.19)). No significant reduction was found in fasting glucose, 2 hours glucose, percent of fat mass, and mean free testosterone after intervention.
The findings of this systematic review show limited evidence about the association between dairy consumption and Polycystic Ovary Syndrome. The interventional studies suggest that a low-dairy/low-starch diet may improve some anthropometric and metabolic measures in women with Polycystic Ovary Syndrome.
我们进行了一项系统评价和荟萃分析，研究了乳制品摄入与多囊卵巢综合征女性的人体测量指标、血糖状态、胰岛素水平和睾酮水平之间的关系。
本研究使用 MEDLINE、Scopus、PubMed、Web of Science 和 Google Scholar 等电子数据库，全面检索了观察性和干预性研究，以确定乳制品消费与多囊卵巢综合征之间关系的研究。对研究低淀粉/低乳制品饮食对多囊卵巢综合征患者影响的临床试验进行了荟萃分析。使用 Stata 版本 16.0（Stata Corporation，德克萨斯州 College Station）进行统计分析，定义统计学意义为 p 值<0.05。
在审查的 1313 篇文献中，我们的系统评价确定了 11 项符合纳入标准的研究，其中包括 6 项病例对照研究、4 项临床试验和 1 项横断面研究。病例对照研究发现乳制品消费与多囊卵巢综合征之间存在有限的关联证据。荟萃分析中临床试验研究的结果表明，减少乳制品和淀粉的摄入可显著改善人体测量和代谢指标，包括平均体重（标准化均数差：-8.43（95%CI：-9.01，-7.86））、体重指数（-3.14（95%CI：-3.35，-2.92））、腰围（-6.63（95%CI：-10.70，-2.57））和腰高比（-0.04（95%CI：-0.07，-0.01））、空腹胰岛素（-18.23（95%CI：-22.11，-14.36））、120 分钟胰岛素（-94.05（95%CI：-157.67，-30.42））、糖化血红蛋白（-0.27（95%CI：-0.37，-0.17））、Ferryman-Gallwey 评分（-2.07（95%CI：-2.98，-1.16））和总睾酮（-9.97（95%CI：-14.75，-5.19））。干预后，空腹血糖、2 小时血糖、体脂百分比和平均游离睾酮无显著降低。
本系统评价的研究结果表明，乳制品摄入与多囊卵巢综合征之间的关联证据有限。干预性研究表明，低乳制品/低淀粉饮食可能改善多囊卵巢综合征女性的一些人体测量和代谢指标。
