Kirshner J J, Goldberg J, Dinter R, Boxer L A
Am J Med Sci. 1986 Jan;291(1):51-5. doi: 10.1097/00000441-198601000-00010.
The pathophysiology of a neutropenic disorder was evaluated in a 60-year-old man using myeloid progenitor cell (CFU-C), colony stimulating activity (CSA), and antineutrophil antibody assays. An immunoglobulin, present in the patient's serum at presentation, was directed against peripheral blood neutrophils, and autologous and allogeneic bone marrow CFU-C. A course of prednisone resulted in resolution of the neutropenia and a disappearance of the cytotoxic antibody. This study suggests that the patient's neutropenic disorder resulted from antibody-mediated destruction of circulating neutrophils and a suboptimal bone marrow granulopoietic response.
利用髓系祖细胞（CFU-C）、集落刺激活性（CSA）和抗中性粒细胞抗体检测，对一名60岁男性的中性粒细胞减少症的病理生理学进行了评估。患者就诊时血清中存在的一种免疫球蛋白，针对外周血中性粒细胞以及自体和异体骨髓CFU-C。泼尼松治疗疗程使中性粒细胞减少症得到缓解，细胞毒性抗体消失。这项研究表明，患者的中性粒细胞减少症是由抗体介导的循环中性粒细胞破坏和骨髓粒细胞生成反应欠佳所致。
