Harmon D C, Weitzman S A, Stossel T P
Br J Haematol. 1984 Oct;58(2):209-15. doi: 10.1111/j.1365-2141.1984.tb06078.x.
Sera from 15 patients with antineutrophil antibodies against peripheral blood neutrophils were incubated with normal bone marrow, and the reaction with marrow precursors was determined. Serum from controls did not deposit IgG on either peripheral blood or marrow myeloid cells. Serum from patients with moderate immune neutropenia with myeloid hyperplasia deposited IgG on neutrophils, bands and metamyelocytes, but not on earlier precursors. Serum from one patient with severe neutropenia and myeloid hypoplasia deposited IgG on myelocytes and promyelocytes as well as more mature cells. Serum from a patient with antineutrophil antibodies which impaired chemotaxis but who did not have neutropenia deposited IgG only on neutrophils and occasional bands. Immune neutropenia may become increasingly severe as antibodies become directed against earlier precursors.
将15例含有抗外周血中性粒细胞抗体的患者血清与正常骨髓一起孵育，并测定其与骨髓前体细胞的反应。对照血清在周围血或骨髓髓系细胞上均未沉积IgG。伴有髓系增生的中度免疫性中性粒细胞减少症患者的血清在中性粒细胞、带状核细胞和晚幼粒细胞上沉积IgG，但不在早期前体细胞上沉积。1例患有严重中性粒细胞减少症和髓系发育不全的患者血清在中幼粒细胞、早幼粒细胞以及更成熟的细胞上沉积IgG。1例含有损害趋化性但无中性粒细胞减少症的抗中性粒细胞抗体患者的血清仅在中性粒细胞和偶尔的带状核细胞上沉积IgG。随着抗体针对更早的前体细胞，免疫性中性粒细胞减少症可能会变得越来越严重。
