Anbiyaee Omid, Ghaedrahmati Farhoodeh, Mousavi Salehi Abdolah, Khodadadi Ali, Kempisty Bartosz, Farzaneh Maryam, Dari Mahrokh Abouali Gale
Cardiovascular Research Center, Namazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Mol Med. 2024 Oct 17. doi: 10.2174/0115665240324990241010041445.
Thyroid cancer is the most prevalent form of endocrine cancer. Therefore, the administration of new therapeutic agents for thyroid cancer patients is necessary. One of the recent successes in thyroid cancer research is the identification of the role of signaling pathways in the pathogenesis of the disease. Emerging evidence reveals that long non-coding RNAs (lncRNAs) can serve as novel therapeutic approaches for the diagnosis and treatment of thyroid cancer. The lncRNA metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) plays key roles in gene expression, RNA processing, and epigenetic regulation. It is believed that MALAT1 can regulate several cancer-related processes, including tumour cell growth, proliferation, and metastasis. MALAT1 is involved in the pathogenesis of thzroid cancers by targeting multiple downstream targets and miRNA/mRNA axes. Here, we summarize the emerging roles of MALAT1 in this cancer.
甲状腺癌是内分泌癌中最常见的类型。因此，有必要为甲状腺癌患者使用新的治疗药物。甲状腺癌研究最近的一项成功是确定了信号通路在该疾病发病机制中的作用。新出现的证据表明，长链非编码RNA（lncRNA）可作为甲状腺癌诊断和治疗的新方法。长链非编码RNA转移相关肺腺癌转录本1（MALAT1）在基因表达、RNA加工和表观遗传调控中起关键作用。据信，MALAT1可以调节多个与癌症相关的过程，包括肿瘤细胞生长、增殖和转移。MALAT1通过靶向多个下游靶点和miRNA/mRNA轴参与甲状腺癌的发病机制。在此，我们总结了MALAT1在这种癌症中新兴的作用。
