Xu Wen-Wen, Jin Jin, Wu Xiao-Yu, Ren Qing-Ling, Farzaneh Maryam
Department of Gynaecology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing , 210029, Jiangsu, China.
Department of Surgical Oncology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.
Cancer Cell Int. 2022 Mar 19;22(1):126. doi: 10.1186/s12935-022-02540-y.
Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcribed RNA molecules play an important role in every level of gene expression. Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) is a highly conserved nucleus-restricted lncRNA that regulates genes at the transcriptional and post-transcriptional levels. High expression of MALAT1 is closely related to numerous human cancers. It is generally believed that MALAT1 expression is associated with CRC cell proliferation, tumorigenicity, and metastasis. MALAT1 by targeting multiple signaling pathways and microRNAs (miRNAs) plays a pivotal role in CRC pathogenesis. Therefore, MALAT1 can be a potent gene for cancer prediction and diagnosis. In this review, we will demonstrate signaling pathways associated with MALAT1 in CRC.
结直肠癌（CRC）是全球最致命且最常见的实体恶性肿瘤之一。迫切需要加快结直肠癌的研发和诊断。长链非编码RNA（lncRNA）作为转录的RNA分子，在基因表达的各个层面都发挥着重要作用。转移相关的肺腺癌转录本1（MALAT1）是一种高度保守的、定位于细胞核的lncRNA，它在转录和转录后水平调控基因。MALAT1的高表达与多种人类癌症密切相关。一般认为，MALAT1的表达与结直肠癌细胞增殖、致瘤性和转移有关。MALAT1通过靶向多种信号通路和微小RNA（miRNA）在结直肠癌发病机制中起关键作用。因此，MALAT1可能是一种用于癌症预测和诊断的有效基因。在本综述中，我们将阐述结直肠癌中与MALAT1相关的信号通路。
