Khamar Tayybeh, Jahani Najmeh, Jafari-Nozad Amir Masoud, Farkhondeh Tahereh, Samarghandian Saeed
Student Research Committee, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Curr Med Chem. 2024 Oct 17. doi: 10.2174/0109298673320502241002075427.
Polycystic Ovary Syndrome (PCOS) is a common endocrinological disorder that affects women of reproductive age and can lead to infertility. The prevalence of PCOS ranges from 5-21% depending on the diagnostic criteria and study population. Clinical manifestations include irregular or absent menstrual periods, obesity, and signs of hyperandrogenism. PCOS can also lead to long-term consequences such as metabolic syndrome, increased risk of cardiovascular diseases, endometrial cancer, diabetes mellitus, and hypertension. Metformin and oral contraceptive pills are the most commonly used drugs for PCOS management, but their efficiency is limited and they have some considerable side effects. Researchers are looking into alternative therapeutic options such as phytochemicals. Curcumin (CUR) is a polyphenolic compound found in the rhizome of Curcuma longa and has shown promising effects for females with PCOS. CUR exerts its anti-PCOS effects through different mechanisms such as reducing oxidative stress and inflammation, balancing hormone levels, and controlling the blood sugar and lipid profile. It can also reduce insulin resistance, regulate menstruation, and improve ovarian morphology and function. Despite its beneficial effects, CUR faces several challenges and limitations in clinical use, such as low bioavailability, instability, and rapid elimination. Therefore, researchers are investigating the potential of CUR nanoformulations and new drug delivery systems to overcome these barriers. With growing evidence regarding the potential role of CUR in PCOS treatment, we decided to provide an updated summary of the recent literature from clinical and preclinical studies on this topic.
多囊卵巢综合征（PCOS）是一种常见的内分泌紊乱疾病，影响育龄女性，可导致不孕。根据诊断标准和研究人群的不同，PCOS的患病率在5%至21%之间。临床表现包括月经不规律或闭经、肥胖以及高雄激素血症的体征。PCOS还可导致长期后果，如代谢综合征、心血管疾病、子宫内膜癌、糖尿病和高血压风险增加。二甲双胍和口服避孕药是治疗PCOS最常用的药物，但其疗效有限且有一些相当严重的副作用。研究人员正在研究替代治疗方案，如植物化学物质。姜黄素（CUR）是一种存在于姜黄根茎中的多酚化合物，对患有PCOS的女性显示出有前景的效果。CUR通过不同机制发挥其抗PCOS作用，如减少氧化应激和炎症、平衡激素水平以及控制血糖和血脂谱。它还可以降低胰岛素抵抗、调节月经并改善卵巢形态和功能。尽管有这些有益作用，但CUR在临床应用中面临一些挑战和限制，如生物利用度低、稳定性差和快速消除。因此，研究人员正在研究CUR纳米制剂和新的药物递送系统克服这些障碍的潜力。随着关于CUR在PCOS治疗中潜在作用的证据越来越多，我们决定提供关于该主题临床和临床前研究最新文献的最新综述。
